Vaccine-induced antibodies to contemporary strains of dengue virus type 4 show a mechanistic correlate of protective immunity.
Vaccine-induced antibodies to contemporary strains of dengue virus type 4 show a mechanistic correlate of protective immunity.
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DOI：
10.1016/j.celrep.2022.110930
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发表时间：
2022-06-07
期刊：
影响因子：
8.8
通讯作者：
de Silva, Aravinda M.
中科院分区：
文献类型：
--
作者：
Gallichotte, Emily N.;Henein, Sandra;Nivarthi, Usha;Delacruz, Matthew;Scobey, Trevor;Bonaparte, Matthew;Moser, Janice;Munteanu, Alina;Baric, Ralph;de Silva, Aravinda M.
登革热病毒的四个血清型(DENV1-4)是由蚊子传播的人类黄病毒。几种四价DENV减毒活疫苗正处于不同的临床开发和批准阶段。在对DENV没有基线免疫的儿童中，一种主要的疫苗(登革热™)对疫苗匹配的DENV4II型(GII)毒株有效，但对疫苗不匹配的DENV4GI型(GI)病毒无效。我们使用一组显示GI或GII包膜(E)蛋白的重组DENV4病毒来定位登革热™诱导的与保护相关的中和抗体。疫苗激发的抗体能更好地中和DENV4 GII病毒，而不是GI病毒。中和差异被映射到位于DENV4 NAB靶向区域内的E蛋白上的5个可变氨基酸，支持这些表位特异性NAB在保护中的机制作用。在对DENV没有基线免疫力的儿童中，接种疫苗诱导的DENV4血清型和基因型特异性NAB水平可预测疫苗效果。
The four dengue virus serotypes (DENV1-4) are mosquito-borne flaviviruses of humans. Several live attenuated tetravalent DENV vaccines are at different stages of clinical development and approval. In children with no baseline immunity to DENVs, a leading vaccine (Dengvaxia™) was efficacious against vaccine-matched DENV4 genotype II (GII) strains but not vaccine-mismatched DENV4 genotype I (GI) viruses. We used a panel of recombinant DENV4 viruses displaying GI or GII envelope (E) proteins to map Dengvaxia™ induced neutralizing antibodies (NAb) linked to protection. The vaccine stimulated antibodies that neutralized the DENV4 GII virus better than the GI virus. The neutralization difference mapped to 5 variable amino acids on E protein located within a region targeted by DENV4 NAbs, supporting a mechanistic role for these epitope-specific NAbs in protection. In children with no baseline immunity to DENVs, levels of DENV4 serotype- and genotype-specific NAbs induced by vaccination are predictive of vaccine efficacy.
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DOI：
10.1126/science.aac5017
发表时间：
2015-09-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Katzelnick LC;Fonville JM;Gromowski GD;Bustos Arriaga J;Green A;James SL;Lau L;Montoya M;Wang C;VanBlargan LA;Russell CA;Thu HM;Pierson TC;Buchy P;Aaskov JG;Muñoz-Jordán JL;Vasilakis N;Gibbons RV;Tesh RB;Osterhaus AD;Fouchier RA;Durbin A;Simmons CP;Holmes EC;Harris E;Whitehead SS;Smith DJ
通讯作者：
Smith DJ
影响因子：
3.8
作者：
Forshey, Brett M.;Reiner, Robert C.;Stoddard, Steven T.
通讯作者：
Stoddard, Steven T.
影响因子：
3.3
作者：
Gilbert, Peter B.;Huang, Ying;Noriega, Fernando
通讯作者：
Noriega, Fernando
影响因子：
6.4
作者：
Morrison, Dennis;Legg, Thomas J.;Lang, Jean
通讯作者：
Lang, Jean
影响因子：
158.5
作者：
Hadinegoro, S. R.;Arredondo-Garcia, J. L.;Saville, M.
通讯作者：
Saville, M.