mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions.
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions.
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DOI：
10.1126/scitranslmed.abm2311
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发表时间：
2022-05-18
影响因子：
17.1
通讯作者：
Alter G
中科院分区：
文献类型：
--
作者：
Kaplonek P;Cizmeci D;Fischinger S;Collier AR;Suscovich T;Linde C;Broge T;Mann C;Amanat F;Dayal D;Rhee J;de St Aubin M;Nilles EJ;Musk ER;Menon AS;Saphire EO;Krammer F;Lauffenburger DA;Barouch DH;Alter G
2019冠状病毒病（COVID-19）疫苗的成功开发大大降低了疫苗部署地区的发病率和死亡率。然而，随着能够逃避疫苗诱导的中和抗体的病毒变体的出现，真实世界的疫苗效力已经开始在两种获批的mRNA平台BNT 162 b2和mRNA-1273之间显示出差异;这些发现表明，由BNT 162 b2和mRNA-1273疫苗诱导的免疫应答的细微变化可能赋予差异保护。考虑到我们对中和之外的额外抗体功能的重要性的新认识，我们在一组医院工作人员中分析了由BNT 162 b2和mRNA-1273疫苗诱导的体液免疫应答的加强后结合和功能能力。这两种疫苗都诱导了对野生型严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）和令人担忧的变种的强烈体液免疫反应。然而，在表位特异性反应中出现了差异，在mRNA-1273受体中观察到更高浓度的受体结合结构域（RBD）和N-末端结构域特异性伊加。与BNT 162 b2受体相比，mRNA-1273疫苗受体中引发中性粒细胞吞噬作用和自然杀伤细胞活化的抗体也增加。RBD特异性抗体耗竭突出了跨mRNA疫苗诱导的非RBD特异性抗体效应子功能的不同作用。这些数据提供了对这些疫苗赋予的保护性免疫的潜在差异的见解。COVID-19 mRNA疫苗诱导强大的体液免疫应答，其表位识别和抗体介导的功能特性存在差异。
The successful development of several coronavirus disease 2019 (COVID-19) vaccines has substantially reduced morbidity and mortality in regions of the world where the vaccines have been deployed. However, in the wake of the emergence of viral variants that are able to evade vaccine-induced neutralizing antibodies, real-world vaccine efficacy has begun to show differences across the two approved mRNA platforms, BNT162b2 and mRNA-1273; these findings suggest that subtle variation in immune responses induced by the BNT162b2 and mRNA-1273 vaccines may confer differential protection. Given our emerging appreciation for the importance of additional antibody functions beyond neutralization, we profiled the post-boost binding and functional capacity of humoral immune responses induced by the BNT162b2 and mRNA-1273 vaccines in a cohort of hospital staff. Both vaccines induced robust humoral immune responses to wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to variants of concern. However, differences emerged across epitope-specific responses, with higher concentrations of receptor binding domain (RBD)- and N-terminal domain-specific IgA observed in recipients of mRNA-1273. Antibodies eliciting neutrophil phagocytosis and natural killer cell activation were also increased in mRNA-1273 vaccine recipients as compared to BNT162b2 recipients. RBD-specific antibody depletion highlighted the different roles of non-RBD-specific antibody effector functions induced across the mRNA vaccines. These data provide insights into potential differences in protective immunity conferred by these vaccines. COVID-19 mRNA vaccines induce robust humoral immune responses with differences in epitope recognition and antibody-mediated functional properties.
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离散的 SARS-CoV-2 抗体滴度与功能性体液稳定性保持一致。
影响因子：
16.6
作者：
Bartsch YC;Fischinger S;Siddiqui SM;Chen Z;Yu J;Gebre M;Atyeo C;Gorman MJ;Zhu AL;Kang J;Burke JS;Slein M;Gluck MJ;Beger S;Hu Y;Rhee J;Petersen E;Mormann B;Aubin MS;Hasdianda MA;Jambaulikar G;Boyer EW;Sabeti PC;Barouch DH;Julg BD;Musk ER;Menon AS;Lauffenburger DA;Nilles EJ;Alter G
通讯作者：
Alter G
DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G
影响因子：
100.3
作者：
Chen, Zeyu;John Wherry, E.
通讯作者：
John Wherry, E.
影响因子：
3.3
作者：
Bhattarai, Nisha;Baral, Prabin;Chapagain, Prem P.
通讯作者：
Chapagain, Prem P.
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group