Biologically meaningful determinants of the in vitro strength of lumbar vertebrae.
Biologically meaningful determinants of the in vitro strength of lumbar vertebrae.
复制标题
腰椎体外强度的具有生物学意义的决定因素。
DOI：
10.1016/8756-3282(91)90044-j
复制
发表时间：
1991
期刊：
影响因子：
4.1
通讯作者：
S. Sørensen
中科院分区：
文献类型：
--
作者：
A. Vesterby;L. Mosekilde;H. Gundersen;F. Melsen;K. Holme;S. Sørensen
应用无偏体视学方法和一个新的体视学参数松质骨星星体积，测量第一腰椎椎体的骨结构，并与第二腰椎椎体的抗压强度进行比较。材料来自8名男性，年龄33-69岁（平均49岁）和7名女性，年龄22-87岁（平均52岁），无恶性或代谢性骨病。从这些个体中，在尸检时获得第一和第二腰椎椎体。记录个体的身高和体重。在未脱钙、7 μ m、Goldner-Trichrome染色的垂直切片上估计以下结构参数：骨小梁体积分数（BV TV%）、平均骨小梁厚度（Tb.日l l t μm）、骨小梁星星体积（V tr mm 3）、骨髓腔星星体积（V m.外侧皮质环平均厚度（μm）。对整个椎体的抗压强度、平均横截面积（cm 2）和灰分密度（g/cm 3）进行估计，并将数据与骨组织形态计量学估计值进行比较。除髓腔星星体积增加外，所有参数均随年龄显著降低。以抗压强度为因变量，所有其他参数为自变量，通过标准多元回归分析表明，体外测试的抗压强度可以从平均皮质厚度、平均横截面积和骨髓腔星星体积或灰分密度预测，当已知个体的身高和性别时，回归系数的平方（r2）为0.95。分层多元回归分析显示，除了年龄和性别，这已进入在第一，平均皮质厚度和小梁星星体积是其次的重要性，多重，平方回归系数（r2）为0.81至0.90。目前的研究，其中包括个人在一个大的年龄跨度，表明平均厚度的外侧皮质环可能是非常重要的压缩强度的整个椎体。然而，必须证明这是否也适用于相同性别和相同年龄段的个体以及骨质疏松症患者。
Applying unbiased Stereological methods and a new stereological parameter, star volume of cancellous bone, the bone structure of the first vertebral body was examined and compared with the compressive strength of the second lumbar vertebra. The material came from eight males, aged 33–69 years (mean 49 years) and seven women, aged 22–87 years (mean 52 years) without malignant or metabolic bone disease. From these individuals, first and second lumbar vertebral body were obtained at autopsy. The heights and weights of the individuals were recorded. The following structural parameters were estimated on undecalcified, seven-μn, Goldner-Trichrome stained vertical sections: fractional volume of trabecular bone (BV TV%), mean trabecular thickness (Tb. Th. l l t μm), trabecular star volume (V tr∗ mm 3), marrow space star volume (V m. space∗ mm 3), and mean thickness of the lateral cortical ring (μm). The compressive strength of whole vertebral body, mean cross sectional area (cm 2), and ash density (g/cm 3) were estimated and the data were compared to bone histomorphometric estimates. A significant decrease with age for all parameters was found except for marrow space star volume, which increased. With compressive strength as the dependent variable and all other parameters as independent variables, it was shown by standard multiple regression analysis that the in vitro tested compressive strength could be predicted from mean cortical thickness, mean cross sectional area, and marrow space star volume or ash density with a multiple, squared coefficient of regression (r 2) of 0.95 when the height and sex of the individual were known. The hierarchical multiple regression analysis disclosed that besides age and sex, which had been entered at first, mean cortical thickness and trabecular star volume were of next importance with a multiple, squared coefficient of regression (r 2) of 0.81 to 0.90. The present study, which includes individuals over a large age-span, suggests that mean thickness of the lateral cortical ring may be of major importance for the compressive strength of whole vertebral bodies. It has to be shown, however, if this is also the case in individuals of identical sex and in the same age span, as well as for patients with osteoporosis.
DOI：
10.1097/00006254-199008000-00016
发表时间：
1990-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
B. Riggs;S. Hodgson;W. O'Fallon;E. Chao;H. Wahner;J. Muhs;S. L. Cedel;L. Joseph Melon
通讯作者：
B. Riggs;S. Hodgson;W. O'Fallon;E. Chao;H. Wahner;J. Muhs;S. L. Cedel;L. Joseph Melon
髂嵴骨活检中的小梁结构：结构参数的个体差异以及随年龄的变化。
影响因子：
4.1
作者：
Parisien,MV;McMahon,D;Pushparaj,N;Dempster,DW
通讯作者：
Dempster,DW