In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases.
In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases.
复制标题
DOI：
10.3390/pharmaceutics10020040
复制
发表时间：
2018-03-30
期刊：
影响因子：
5.4
通讯作者：
Aderibigbe BA
中科院分区：
文献类型：
--
作者：
Aderibigbe BA
已经开发了原位凝胶药物递送系统，其可以绕过血脑屏障，将治疗剂递送到所需部位，降低外周毒性并控制药物释放动力学。用于治疗神经系统疾病的一些治疗剂遭受差的生物利用度。几位研究人员的临床前报告已经证明，使用原位凝胶通过鼻-脑途径将药物递送到大脑具有很大的前景。然而，鼻粘膜毒性、药物向特定脑区域的运输和所需剂量的确定等安全性问题是设计这些凝胶时必须考虑的因素。本综述将重点介绍用于通过鼻-脑途径递送治疗剂的原位凝胶、临床前报告和挑战。
In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics have been developed. Some of the therapeutics used to treat neurological diseases suffer from poor bioavailability. Preclinical reports from several researchers have proven that the delivery of drugs to the brain via the nose-to-brain route using in situ gels holds great promise. However, safety issues on the toxicity of the nasal mucosa, transportation of the drugs to specific brain regions and determination of the required dose are factors that must be considered when designing these gels. This review will be focused on in situ-based gels that are used for the delivery of therapeutics via the nose-to-brain route, preclinical reports and challenges.
登录
查看更多内容
影响因子：
4.8
作者：
Haque, Shadabul;Md, Shadab;Baboota, Sanjula
通讯作者：
Baboota, Sanjula
影响因子：
12.4
作者：
Hadaczek, P;Yamashita, Y;Bankiewicz, K
通讯作者：
Bankiewicz, K
影响因子：
3.3
作者：
Chen, Xi;Zhi, Feng;Yang, Yilin
通讯作者：
Yang, Yilin
DOI：
10.3390/molecules23010040
发表时间：
2017-12-25
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Haddad F;Sawalha M;Khawaja Y;Najjar A;Karaman R
通讯作者：
Karaman R
影响因子：
4.5
作者：
Kaur, Prabhjot;Garg, Tarun;Goyal, Amit K.
通讯作者：
Goyal, Amit K.