Epidemiological profile and burden of rotavirus diarrhea in Vietnam: 5 years of sentinel hospital surveillance, 1998-2003.
Epidemiological profile and burden of rotavirus diarrhea in Vietnam: 5 years of sentinel hospital surveillance, 1998-2003.
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越南轮状病毒腹泻的流行病学概况和负担：5 年哨点医院监测，1998-2003 年。
DOI：
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发表时间：
2005
影响因子：
6.4
通讯作者：
R. Glass
中科院分区：
文献类型：
--
作者：
Nguyen Van Man;L. T. Luan;D. D. Trach;N. T. Thanh;P. Van Tu;N. Long;D. Anh;T. Fischer;B. Ivanoff;J. Gentsch;R. Glass
5年来，我们在越南4个城市的6家医院对轮状病毒进行了哨点监测。从100 000名因腹泻入院的5岁以下儿童的粪便样本中提取了轮状病毒筛查。总体而言，55%的样本呈阳性，不同地点之间轮状病毒的检出率几乎没有差异（44%-62%）。在越南，轮状病毒感染的特征更接近于发达国家的特征，而不是发展中国家的特征：儿童感染的年龄较大，在粪便样本中检测到轮状病毒的百分比非常高，轮状病毒菌株似乎是常见类型，混合感染的发生较少。据估计，越南每年有5300-6800名5岁以下儿童死于轮状病毒感染，占该年龄组死亡总数的8%-11%（按5岁计算，每个儿童的累积风险为200 / 1至285 / 1）。目前正在进行进一步的研究，以记录该病的经济成本，并评估致命病例和较轻病例的负担。研究结果将为轮状病毒疫苗的未来测试和潜在使用提供信息。
For 5 years, we have conducted sentinel surveillance for rotavirus at 6 hospitals in 4 cities in Vietnam. Stool samples obtained from >10,000 children <5 years old who were admitted to the hospital with diarrhea have been screened for rotavirus. Overall, 55% of samples were positive, and there was little variability in rates of detection of rotavirus between sites (44%-62%). In Vietnam, the characteristics of rotavirus infection more closely resemble those seen in developed countries, rather than those seen in developing countries: children become infected at an older age, the percentage of stool samples in which rotavirus is detected is extremely high, and the rotavirus strains appear to be the common types, with fewer mixed infections occurring. It is estimated that 5300-6800 children <5 years old die of rotavirus infection each year in Vietnam, representing 8%-11% of all deaths in this age group (cumulative risk per child by age 5 years, 1 in 200 to 1 in 285). Additional studies are ongoing to document the economic cost of the disease and to assess the burden of both fatal cases and milder cases of disease. Study outcomes will provide information for future testing and potential use of a rotavirus vaccine.
泰国士兵和平民CVD 103-HgR口服霍乱活疫苗不同免疫方案的安全性和免疫原性。
DOI：
10.1093/infdis/165.6.1042
发表时间：
1992
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Su-Arehawaratana,P;Singharaj,P;Taylor,DN;Hoge,C;Trofa,A;Kuvanont,K;Migasena,S;Pitisuttitham,P;Lim,YL;Losonsky,G
通讯作者：
Losonsky,G