Role of CpG deserts in the epigenetic transgenerational inheritance of differential DNA methylation regions.
Role of CpG deserts in the epigenetic transgenerational inheritance of differential DNA methylation regions.
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DOI：
10.1186/1471-2164-15-692
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发表时间：
2014-08-20
期刊：
影响因子：
4.4
通讯作者：
Guerrero-Bosagna C
中科院分区：
文献类型：
--
作者：
Skinner MK;Guerrero-Bosagna C
以前发现各种环境毒物通过精子中存在的差异DNA甲基化区域（DMR）（称为表突变）促进疾病的表观遗传跨代遗传。进一步研究了在许多先前研究中鉴定的精子和体细胞中的跨代表位突变。来自六种不同环境暴露的表位突变被发现主要是暴露特异性的，重叠可以忽略不计。目前的报告描述了所有独特的表位突变的主要基因组特征（535），即精子和体细胞中与跨代疾病相关的CpG密度非常低（<10 CpG/100 bp）。发现这些表突变的基因组位置包含DMR，其在非常低密度CpG的一般区域内具有小的CpG簇。这些表位突变对基因表达的潜在作用被认为是重要的。观察结果表明，称为“CpG沙漠”的低密度CpG区域具有潜在的调节作用。这些地区的潜在的进化起源进行了讨论。
Previously a variety of environmental toxicants were found to promote the epigenetic transgenerational inheritance of disease through differential DNA methylation regions (DMRs), termed epimutations, present in sperm. The transgenerational epimutations in sperm and somatic cells identified in a number of previous studies were further investigated. The epimutations from six different environmental exposures were found to be predominantly exposure specific with negligible overlap. The current report describes a major genomic feature of all the unique epimutations identified (535) as a very low (<10 CpG/100 bp) CpG density in sperm and somatic cells associated with transgenerational disease. The genomic locations of these epimutations were found to contain DMRs with small clusters of CpG within a general region of very low density CpG. The potential role of these epimutations on gene expression is suggested to be important. Observations suggest a potential regulatory role for lower density CpG regions termed “CpG deserts”. The potential evolutionary origins of these regions is also discussed.
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影响因子：
3.7
作者：
Manikkam M;Guerrero-Bosagna C;Tracey R;Haque MM;Skinner MK
通讯作者：
Skinner MK
影响因子：
9.3
作者：
Skinner MK;Manikkam M;Tracey R;Guerrero-Bosagna C;Haque M;Nilsson EE
通讯作者：
Nilsson EE
DOI：
10.1016/j.reprotox.2012.08.010
发表时间：
2012-12
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Manikkam M;Tracey R;Guerrero-Bosagna C;Skinner MK
通讯作者：
Skinner MK
影响因子：
3.7
作者：
Manikkam M;Tracey R;Guerrero-Bosagna C;Skinner MK
通讯作者：
Skinner MK
影响因子：
12.3
作者：
Skinner MK;Manikkam M;Haque MM;Zhang B;Savenkova MI
通讯作者：
Savenkova MI