Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations.
Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations.
复制标题
DOI：
10.1016/j.reprotox.2012.08.010
复制
发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Skinner MK
中科院分区：
文献类型：
--
作者：
Manikkam M;Tracey R;Guerrero-Bosagna C;Skinner MK
众所周知，环境化合物可以促进疾病的表观遗传和跨代遗传。目前的研究旨在确定“农药混合物”(杀虫剂氯菊酯和驱虫剂N，N-二乙基间甲苯酰胺，DEET)是否促进精子中疾病的表观遗传和相关的DNA甲基化表观突变。妊娠F0代雌性大鼠在胎儿性腺性别测定过程中暴露，并对F1代和F3代的发病率进行评估。农药谱系F1和F3代动物的总发病率显著增加。青春期异常、睾丸疾病和卵巢疾病(原始卵泡丢失和多囊卵巢疾病)在F3代动物中增加。对农药谱系F3代精子表观基因组的分析确定了363个差异DNA甲基化区域(DMR)，称为表观突变。观察表明，混合杀虫剂(氯菊酯和DEET)可以促进成人型疾病的表观遗传遗传和祖先环境暴露的潜在精子表观遗传生物标志物。
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a “pesticide mixture” (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm. Gestating F0 generation female rats were exposed during fetal gonadal sex determination and the incidence of disease evaluated in F1 and F3 generations. There were significant increases in the incidence of total diseases in animals from pesticide lineage F1 and F3 generation animals. Pubertal abnormalities, testis disease, and ovarian disease (primordial follicle loss and polycystic ovarian disease) were increased in F3 generation animals. Analysis of the pesticide lineage F3 generation sperm epigenome identified 363 differential DNA methylation regions (DMR) termed epimutations. Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.
登录
查看更多内容
影响因子：
--
作者：
Issam, Chargui;Zohra, Haouas;Hassen, Ben Cheikh
通讯作者：
Hassen, Ben Cheikh
影响因子：
6.7
作者：
Kleiman, Sandra E.;Maymon, Batia Bar-Shira;Yogev, Leah
通讯作者：
Yogev, Leah
DOI：
10.1016/j.bbagrm.2011.03.007
发表时间：
2011-08
影响因子：
4.7
作者：
Hauser, Marie-Theres;Aufsatz, Werner;Jonak, Claudia;Luschnig, Christian
通讯作者：
Luschnig, Christian
影响因子：
3.8
作者：
Abou-Donia, MB;Goldstein, LB;Khan, WA
通讯作者：
Khan, WA
影响因子：
3.7
作者：
Guerrero-Bosagna, Carlos;Settles, Matthew;Skinner, Michael K.
通讯作者：
Skinner, Michael K.