Mechanisms of Nicotine Regulation of Dopamine Release in Neostriatum
Mechanisms of Nicotine Regulation of Dopamine Release in Neostriatum
复制标题
尼古丁调节新纹状体多巴胺释放的机制
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
L. Vickery
中科院分区：
文献类型：
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作者：
T. Westfall;H. Perry;L. Vickery
研究了尼古丁和烟碱激动剂二甲基苯基哌嗪 (DMPP) 诱发大鼠纹状体切片释放多巴胺的机制。通过三个独立的程序评估多巴胺的释放：1）从与标记胺（新吸收的多巴胺）预孵育的切片中释放[3H]多巴胺； 2）通过高压液相色谱结合电化学检测（内源性多巴胺）测量内源性递质的释放，以及3）通过用[3H]酪氨酸（新合成的多巴胺）灌注切片连续形成[3H]多巴胺的释放。观察到两种烟碱激动剂都能引起大鼠纹状体切片释放多巴胺。获得的结果与这些药物通过两种机制释放多巴胺的解释一致，一种机制在低药物浓度下观察到，另一种在药物浓度高时观察到。
The mechanism(s) of the evoked release of dopamine from rat striatal slices by nicotine and the nicotinic agonist dimethylphenylpiperazinium (DMPP) has been studied. Release of dopamine was assessed by three separate procedures: 1) release of [3H]dopamine from slices preincubated with the labeled amine (newly taken up dopamine); 2) release of endogenous transmitter measured by high pressure liquid chromatography coupled to electrochemical detection (endogenous dopamine), and 3) release of [3H]dopamine continuously formed by superfusion of slices with [3H]tyrosine (newly synthesized dopamine). Both nicotinic agonists were observed to cause a release of dopamine from rat striatal slices. The results obtained are consistent with the interpretation that these agents release dopamine by two mechanisms, one seen at low and the other seen at high concentrations of the drugs.
烟碱胆碱能受体激活后，大鼠纹状体切片释放多巴胺和 5-羟色胺。
DOI：
10.1016/0306-3623(83)90037-x
发表时间：
1983
期刊：
General pharmacology
影响因子：
--
作者：
Westfall,TC;Grant,H;Perry,H
通讯作者：
Perry,H