Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.
Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.
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DOI：
10.1016/j.chom.2018.09.009
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发表时间：
2018-10-10
影响因子：
30.3
通讯作者：
Xavier RJ
中科院分区：
文献类型：
--
作者：
Schirmer M;Denson L;Vlamakis H;Franzosa EA;Thomas S;Gotman NM;Rufo P;Baker SS;Sauer C;Markowitz J;Pfefferkorn M;Oliva-Hemker M;Rosh J;Otley A;Boyle B;Mack D;Baldassano R;Keljo D;LeLeiko N;Heyman M;Griffiths A;Patel AS;Noe J;Kugathasan S;Walters T;Huttenhower C;Hyams J;Xavier RJ
评估溃疡性结肠炎(UC)的进展风险和确定最佳治疗方案具有挑战性，因为许多患者对治疗表现出不完全的反应。作为PROTECT(预测对标准化结肠炎治疗的反应)研究的一部分，我们评估了肠道微生物群在405名儿童、新发、未接受治疗的UC患者的病程中的作用。患者在治疗开始后被监测了一年，并从粪便样本和直肠活检中分析了微生物分类组成。肠道核心微生物的枯竭和口腔典型细菌的扩张与基线疾病严重程度相关。缓解和难治性疾病与特定物种的时间变化有关，这可能意味着治疗效果，并且在结肠切除术前观察到微生物组变异性显著增加。最后，微生物与疾病相关血清标志物的相关性表明UC中宿主与微生物的相互作用。这些见解将有助于改进现有的治疗方法，并开发指导最佳医疗保健的治疗方法。许多患者对溃疡性结肠炎(UC)治疗表现出不完全反应。Schirmer等人。研究肠道微生物群在两种传统疗法治疗儿童UC中的作用。基线和纵向微生物趋势与疾病的严重程度和进展有关，包括缓解和结肠切除要求。这些见解可能会激励新的治疗方法。
Evaluating progression risk and determining optimal therapy for ulcerative colitis (UC) is challenging as many patients exhibit incomplete responses to treatment. As part of the PROTECT (Predicting Response to Standardized Colitis Therapy) Study, we evaluated the role of the gut microbiome in disease course for 405 pediatric, new-onset, treatment-naive UC patients. Patients were monitored for one year upon treatment initiation, and microbial taxonomic composition was analyzed from fecal samples and rectal biopsies. Depletion of core gut microbes and expansion of bacteria typical of the oral cavity were associated with baseline disease severity. Remission and refractory disease were linked to species-specific temporal changes that may be implicative of therapy efficacy, and a pronounced increase in microbiome variability was observed prior to colectomy. Finally, microbial associations with disease-associated serological markers suggest host-microbial interactions in UC. These insights will help improve existing treatments and develop therapeutic approaches guiding optimal medical care. Many patients exhibit incomplete responses to ulcerative colitis (UC) therapy. Schirmer et al. investigate the gut microbiome's role in pediatric UC treated with two conventional therapies. Baseline and longitudinal microbial trends are implicated in disease severity and progression, including remission and colectomy requirement. These insights may motivate new therapeutic approaches.
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影响因子：
16.6
作者：
Duvallet C;Gibbons SM;Gurry T;Irizarry RA;Alm EJ
通讯作者：
Alm EJ
DOI：
10.1126/science.aan4526
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Suda W;Luo C;Kawaguchi T;Motoo I;Narushima S;Kiguchi Y;Yasuma K;Watanabe E;Tanoue T;Thaiss CA;Sato M;Toyooka K;Said HS;Yamagami H;Rice SA;Gevers D;Johnson RC;Segre JA;Chen K;Kolls JK;Elinav E;Morita H;Xavier RJ;Hattori M;Honda K
通讯作者：
Honda K
DOI：
10.1016/j.cgh.2008.04.032
发表时间：
2008-10
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Dubinsky MC;Kugathasan S;Mei L;Picornell Y;Nebel J;Wrobel I;Quiros A;Silber G;Wahbeh G;Katzir L;Vasiliauskas E;Bahar R;Otley A;Mack D;Evans J;Rosh J;Hemker MO;Leleiko N;Crandall W;Langton C;Landers C;Taylor KD;Targan SR;Rotter JI;Markowitz J;Hyams J;Western Regional Pediatric IBD Research Alliance;Pediatric IBD Collaborative Research Group;Wisconsin Pediatric IBD Alliance
通讯作者：
Wisconsin Pediatric IBD Alliance
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.5
作者：
Kaiko GE;Ryu SH;Koues OI;Collins PL;Solnica-Krezel L;Pearce EJ;Pearce EL;Oltz EM;Stappenbeck TS
通讯作者：
Stappenbeck TS