Decreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity.
Decreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity.
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DOI：
10.1167/iovs.63.12.23
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发表时间：
2022-11-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
早产儿视网膜病变（ROP）可导致失明。花生四烯酸（ARA）和二十二碳六烯酸（DHA）调节视网膜炎症和血管生成。本研究的目的是调查早产儿红细胞膜（RBCM）中的ARA和DHA。
这项前瞻性观察研究根据ROP严重程度以及RBCM中ARA和DHA的均值和三分位数将婴儿分组。
尽管各组间RBCM的ARA均值±标准差不同（无ROP组为17.9%±0.7%，2型ROP组为17.4%±0.8%，1型ROP组为16.7%±1.0%；P<0.001），但RBCM的DHA均值相似（P = 0.161）。1型ROP患儿处于ARA和DHA最低三分位数的可能性高于处于最高三分位数的可能性（ARA：44%比5.6%；DHA：22%比5.6%）。在所有ROP组中，ARA和DHA在出生后的第一个月内均下降。在第1周，1型和2型ROP组的ARA低于无ROP组（分别为18%±2%和19%±3%比21%±2%；所有P<0.05）。在第2周，1型ROP组的DHA和ARA低于无ROP组（分别为3%±1%比4%±1%，P = 0.03；16%±1%比19%±1%，P<0.01）。RBCM的ARA%≥17与任何ROP的风险降低45%相关。随着估计的4周ARA%均值增加1%，ROP的几率降低70%（比值比 = 0.30；95%置信区间，0.1 - 0.7）。
患有严重ROP的婴儿比无ROP的婴儿具有更低的ARA和DHA水平。ARA和DHA可能协同作用以预防ROP。
Retinopathy of prematurity (ROP) can lead to blindness. Arachidonic acid (ARA) and docosahexaenoic acid (DHA) regulate retinal inflammation and angiogenesis. The aim of this study was to investigate red blood cell membrane (RBCM) ARA and DHA in preterm infants. This prospective observational study divided infants into groups by ROP severity and RBCM ARA and DHA means and terciles. Although the mean ± SD RBCM ARA was different between groups (no ROP, 17.9% ± 0.7%, vs. type 2 ROP, 17.4% ± 0.8%, vs. type 1 ROP, 16.7% ± 1.0%; P < 0.001), the mean RBCM DHA was similar (P = 0.161). Infants with type 1 ROP were more likely to be in the lowest ARA and DHA terciles than in the highest (ARA, 44% vs. 5.6%; DHA, 22% vs. 5.6%). ARA and DHA declined over the first month of life in all ROP groups. At week 1, ARA was lower in the type 1 and type 2 ROP groups compared with the no-ROP group (18% ± 2% and 19% ± 3% vs. 21% ± 2%, respectively; P < 0.05 for all). At week 2, DHA and ARA were lower in the type I ROP group compared with the no-ROP group (3% ± 1% vs. 4% ± 1%, P = 0.03 and 16% ± 1% vs. 19% ± 1%, respectively; P < 0.01). A RBCM ARA% ≥ 17 was associated with a 45% reduction in any ROP. As the estimated 4-week ARA% mean increased by 1%, the odds of ROP decreased by 70% (odds ratio = 0.30; 95% confidence interval, 0.1–0.7). Infants with severe ROP have lower ARA and DHA levels than infants without ROP. ARA and DHA may act synergistically to protect against ROP.
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