Development of a mild and versatile directed cycloaddition approach to pyridines.
Development of a mild and versatile directed cycloaddition approach to pyridines.
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DOI：
10.1002/chem.201403916
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发表时间：
2014-09-26
影响因子：
4.3
通讯作者：
Harrity, Joseph P. A.
中科院分区：
文献类型：
--
作者：
Bachollet, Sylvestre P. J. T.;Vivat, Jerome F.;Cocker, Dean C.;Adams, Harry;Harrity, Joseph P. A.
The aza-Diels–Alder cycloaddition of 1,2,4-triazines with alkynes offers a rapid and convenient method for the synthesis of highly substituted pyridines, but often requires harsh conditions and long reaction times. The present study offers a solution to these limitations by use of a temporary tether established by a Lewis acid–base complexation of in situ generated alkynylboranes and triazines bearing a Lewis basic donor. The cycloaddition reactions take place within 20 min at 40 °C and provide direct access to a broad range of pyridines with complete and predictable regiocontrol. The carbon—boron bond can be further functionalised by cross-coupling allowing further functionality to be introduced after cycloaddition.
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影响因子：
4.9
作者：
Delaney, Patrick M.;Moore, Jane E.;Harrity, Joseph P. A.
通讯作者：
Harrity, Joseph P. A.
影响因子：
2.1
作者：
Henry, GD
通讯作者：
Henry, GD
影响因子：
16.6
作者：
Kirkham, James D.;Butlin, Roger J.;Harrity, Joseph P. A.
通讯作者：
Harrity, Joseph P. A.
影响因子：
3.6
作者：
Diring, Stephane;Retailleau, Pascal;Ziessel, Raymond
通讯作者：
Ziessel, Raymond
影响因子：
5.2
作者：
Crépin DF;Harrity JP
通讯作者：
Harrity JP