Treatment of children with port-wine stains using the flashlamp-pulsed tunable dye laser.
Treatment of children with port-wine stains using the flashlamp-pulsed tunable dye laser.
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使用闪光灯脉冲可调谐染料激光器治疗患有葡萄酒色斑的儿童。
DOI：
10.1056/nejm198902163200702
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gilchrest,BA
中科院分区：
文献类型：
--
作者：
Tan,OT;Sherwood,K;Gilchrest,BA
35名儿童，3个月至14岁，与毁容葡萄酒色斑治疗闪光灯脉冲可调谐染料激光。在对每个病变区域平均进行6.5次激光治疗后，所有患者的污渍都完全清除;骨赘上的皮肤所需的治疗次数约为脸颊皮肤的一半。小于7岁的儿童需要的治疗次数（平均值±标准差，5.8±1.1）少于大于7岁的儿童（7.1±1.1; P<0.05）。33名（94.3%）儿童的治疗皮肤在质地和颜色上与邻近的正常皮肤相同，而2名（5.7%）儿童在激光治疗后不久意外创伤的区域有小的、孤立的、凹陷的疤痕。唯一的另一个副作用是短暂的色素沉着过度，发生在20名患者中这些结果可以归因于闪光灯脉冲可调谐染料激光器的两个显著特征：发射波长为577 nm，理论上对于血管内目标氧合血红蛋白的选择性吸收是理想的，脉冲持续时间为360 μsec，这与真皮血管的热松弛时间紧密匹配，因此避免了扩散性非特异性热坏死和随后的被治疗皮肤的瘢痕形成。（N Engl J Med 1989;320：416-21.）
Thirty-five children, three months to 14 years of age, with disfiguring port-wine stains were treated with a flashlamp-pulsed tunable dye laser. All had complete clearing of the stains after an average of 6.5 laser treatments to each lesional area; skin over bony prominences required approximately half as many sessions as skin on the cheek. Children less than seven years old required fewer sessions (mean ±SD, 5.8±1.1) than older children (7.1±1.1; P<0.05). Treated skin was identical in texture and color to adjacent normal skin in 33 (94.3 percent) of the children, whereas 2 (5.7 percent) had small, isolated, depressed scars in areas accidentally traumatized soon after laser treatment. The only other side effect was transient hyperpigmentation, which occurred in 20 patients (57 percent).These results can be attributed to two distinguishing characteristics of the flashlamp-pulsed tunable dye laser: an emission wavelength of 577 nm, theoretically ideal for selective absorption by the intravascular target oxyhemoglobin, and a pulse duration of 360 μsec, which closely matches the thermal relaxation time for dermal blood vessels and hence avoids diffuse nonspecific thermal necrosis with subsequent scarring of the treated skin. (N Engl J Med 1989;320:416–21.)
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影响因子：
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