Whole-genome association mapping in elite inbred crop varieties.
Whole-genome association mapping in elite inbred crop varieties.
复制标题
优良自交作物品种的全基因组关联图谱。
作者：
Waugh R
我们先前已经表明，在优良栽培大麦（大麦）基因库中的连锁不平衡（LD）平均延伸<1-5 cM。基于这些信息，我们开发了一个全基因组关联研究平台，该平台包括我们在3060个全基因组单核苷酸多态性（SNP）标记位点表征的精英品系的集合。询问这个数据集表明，显着的人口子结构内存在的精英基因库和多样性和LD变化很大，在每一个大麦的7条染色体。然而，我们还表明，一个亚群组成的只有两排的春天种质是结构不太好，适合全基因组关联研究，而不需要广泛的统计干预，以占结构。在目前的标记密度，两行的春天人口是适合精细映射简单的性状，位于遗传着丝粒以外的分辨率，是足够的候选基因识别，利用保守的同线性与完全测序的模型基因组和新兴的大麦物理地图。
We have previously shown that linkage disequilibrium (LD) in the elite cultivated barley (Hordeum vulgare) gene pool extends, on average, for <1–5 cM. Based on this information, we have developed a platform for whole genome association studies that comprises a collection of elite lines that we have characterized at 3060 genome-wide single nucleotide polymorphism (SNP) marker loci. Interrogating this data set shows that significant population substructure is present within the elite gene pool and that diversity and LD vary considerably across each of the seven barley chromosomes. However, we also show that a subpopulation comprised of only the two-rowed spring germplasm is less structured and well suited to whole genome association studies without the need for extensive statistical intervention to account for structure. At the current marker density, the two-rowed spring population is suited for fine mapping simple traits that are located outside of the genetic centromeres with a resolution that is sufficient for candidate gene identification by exploiting conservation of synteny with fully sequenced model genomes and the emerging barley physical map.
影响因子：
30.8
作者：
Yu, JM;Pressoir, G;Buckler, ES
通讯作者：
Buckler, ES
利用油籽芸苔属物种的全基因组关联。
影响因子：
3.1
作者：
E. Balázs;Wallace Cowling
通讯作者：
Wallace Cowling