Mussel-inspired cortical bone-adherent bioactive composite hydrogels promote bone augmentation through sequential regulation of endochondral ossification.
Mussel-inspired cortical bone-adherent bioactive composite hydrogels promote bone augmentation through sequential regulation of endochondral ossification.
复制标题
贻贝启发的皮质骨粘附的生物活性复合水凝胶通过连续调节内软骨骨化促进骨增强。
DOI：
10.1016/j.mtbio.2023.100843
复制
发表时间：
2023-12
影响因子：
8.2
通讯作者：
Zhao, Fujian
中科院分区：
文献类型：
--
作者：
Tan, Shuyi;Qiu, Yonghao;Xiong, Huacui;Wang, Chunhui;Chen, Yifan;Wu, Wangxi;Yang, Zhen;Zhao, Fujian
软骨内成骨（ECO）在骨增强中起着不可或缺的作用，其过程包括间充质干细胞（MSC）凝聚、软骨细胞分化、软骨细胞肥大和矿化骨形成。因此，加速这些步骤将通过ECO加速成骨过程。本研究以贻贝的黏附机制为灵感，将微纳米BG与多巴胺修饰明胶分别涂覆在醛修饰透明质酸上，制备了具有生物活性的玻璃多巴胺水凝胶。通过体外和体内实验，我们证实在骨增强位置植入后，水凝胶可以牢固地附着在骨皮质表面而不滑动。此外，在ECO早期，干细胞的凝结和肥大加速。随后，促进增生性软骨细胞的成骨分化，加速后期ECO过程，实现更多的骨增强。本实验为骨增强材料的设计提供了新的思路。制备了BG-Dopa水凝胶，该水凝胶能牢固附着于皮质骨，并依次促进ECO过程，获得较好的骨增强效果。
Endochondral ossification (ECO) plays an integral part in bone augmentation, which undergoes sequential processes including mesenchymal stem cells (MSC) condensation, chondrocyte differentiation, chondrocyte hypertrophy, and mineralized bone formation. Thus, accelerating these steps will speed up the osteogenesis process through ECO. Herein, inspired by the marine mussels' adhesive mechanism, a bioactive glass-dopamine (BG-Dopa) hydrogel was prepared by distributing the micro-nano BG to aldehyde modified hyaluronic acid with dopamine-modified gelatin. By in vitro and in vivo experiments, we confirm that after implanting in the bone augmentation position, the hydrogel can adhere to the cortical bone surface firmly without sliding. Moreover, the condensation and hypertrophy of stem cells were accelerated at the early stage of ECO. Whereafter, the osteogenic differentiation of the hypertrophic chondrocytes was promoted, which lead to accelerating the late stage of ECO process to achieve more bone augmentation. This experiment provides a new idea for the design of bone augmentation materials. A BG-Dopa hydrogel was fabricated which could adhere to the cortical bone firmly and promoted the process of ECO sequentially to get better bone augmentation results.
登录
查看更多内容
DOI：
10.1002/advs.202300897
发表时间：
2023-08
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Dai B;Zhu Y;Li X;Liang Z;Xu S;Zhang S;Zhang Z;Bai S;Tong W;Cao M;Li Y;Zhu X;Liu W;Zhang Y;Chang L;Yung PS;Ki-Wai Ho K;Xu J;Ngai T;Qin L
通讯作者：
Qin L
具有仿生弹性体表面的 3D 打印光致发光生物活性支架，用于增强骨组织工程
DOI：
10.1016/j.msec.2019.110153
发表时间：
2020-01-01
影响因子：
7.9
作者：
Chen, Mi;Zhao, Fujian;Lei, Bo
通讯作者：
Lei, Bo
影响因子：
17.1
作者：
Renner-Rao, Max;Jehle, Franziska;Harrington, Matthew J.
通讯作者：
Harrington, Matthew J.
影响因子：
5.3
作者：
Liu X;Du Z;Yi X;Sheng T;Yuan J;Jia J
通讯作者：
Jia J
影响因子：
6.2
作者：
Hayata, Tadayoshi;Ezura, Yoichi;Noda, Masaki
通讯作者：
Noda, Masaki