Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis.
Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis.
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DOI：
10.1371/journal.pone.0162949
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Singh KP
中科院分区：
文献类型：
--
作者：
Tabatabai MA;Kengwoung-Keumo JJ;Oates GR;Guemmegne JT;Akinlawon A;Ekadi G;Fouad MN;Singh KP
美国的某些人群承受着不成比例的癌症负担。这项工作对 1999 年至 2012 年美国 38 个州、哥伦比亚特区和美国 8 个地理区域按种族（白人和黑人）、性别（男性和女性）以及日常吸烟流行率划分的肺癌和支气管癌年龄调整发病率的动态进行了建模和分析。数据从美国疾病控制和预防中心的美国癌症统计部门获得，反映了大约 77% 的美国人口，构成了一个具有代表性的样本用于推断肺癌和支气管癌（以下称为肺癌）的发病率。使用纵向线性混合效应模型来研究肺癌发病率，并估计发病率与时间、种族、性别和每日吸烟率的函数关系。 1999 年至 2012 年间，所有州和地区的肺癌年龄调整发病率均有所下降。然而，种族和性别差异仍然存在。在所有州以及美国八个地理区域中的五个地区，白人的这种癌症的年龄调整发病率仍然低于黑人。黑人和白人男性之间的发病率差异明显大于黑人和白人女性之间的差异，其中黑人男性的发病率在所有亚组中最高。假设肺癌发病率保持在合理范围内，该模型预测白人发病率的性别差距将在 2018 年中期消失，黑人发病率的性别差距将在 2026 年消失。然而，黑人和白人男性肺癌发病率的种族差距仍将存在。在所有地理区域中，中南部肺癌总体发病率最高，白人发病率最高，而中西部黑人发病率最高。 1999年至2012年间，男女每日吸烟率均呈下降趋势。然而，在所有时间点，男性吸烟率均明显高于女性。每日吸烟率最高和最低的地区分别是中南部和新英格兰地区。所有地理区域的肺癌发病率与吸烟率之间均存在显着相关性，表明吸烟对区域肺癌发病率有很大影响。尽管美国各地按年龄调整的肺癌发病率有所下降，但种族和性别差异仍然存在。这种纵向模型可以帮助卫生专业人员和政策制定者预测未来五到十年美国肺癌的年龄调整发病率。
Certain population groups in the United States carry a disproportionate burden of cancer. This work models and analyzes the dynamics of lung and bronchus cancer age-adjusted incidence rates by race (White and Black), gender (male and female), and prevalence of daily smoking in 38 U.S. states, the District of Columbia, and across eight U.S. geographic regions from 1999 to 2012. Data, obtained from the U.S. Cancer Statistics Section of the Centers for Disease Control and Prevention, reflect approximately 77% of the U.S. population and constitute a representative sample for making inferences about incidence rates in lung and bronchus cancer (henceforth lung cancer). A longitudinal linear mixed-effects model was used to study lung cancer incidence rates and to estimate incidence rate as a function of time, race, gender, and prevalence of daily smoking. Between 1999 and 2012, age-adjusted incidence rates in lung cancer have decreased in all states and regions. However, racial and gender disparities remain. Whites continue to have lower age-adjusted incidence rates for this cancer than Blacks in all states and in five of the eight U.S. geographic regions. Disparities in incidence rates between Black and White men are significantly larger than those between Black and White women, with Black men having the highest incidence rate of all subgroups. Assuming that lung cancer incidence rates remain within reasonable range, the model predicts that the gender gap in the incidence rate for Whites would disappear by mid-2018, and for Blacks by 2026. However, the racial gap in lung cancer incidence rates among Black and White males will remain. Among all geographic regions, the Mid-South has the highest overall lung cancer incidence rate and the highest incidence rate for Whites, while the Midwest has the highest incidence rate for Blacks. Between 1999 and 2012, there was a downward trend in the prevalence of daily smokers in both genders. However, males have significantly higher rates of cigarette smoking than females at all time points. The highest and lowest prevalence of daily smoking are found in the Mid-South and New England, respectively. There was a significant correlation between lung cancer incidence rates and smoking prevalence in all geographic regions, indicating a strong influence of cigarette smoking on regional lung cancer incidence rates. Although age-adjusted incidence rates in lung cancer have decreased throughout the U.S., racial and gender disparities remain. This longitudinal model can help health professionals and policy makers make predictions of age-adjusted incidence rates for lung cancer in the U.S. in the next five to ten years.
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影响因子：
--
作者：
Farjah, Farhood;Wood, Douglas E.;Flum, David R.
通讯作者：
Flum, David R.
影响因子：
1.9
作者：
Freeman, Harold P;Chu, Kenneth C
通讯作者：
Chu, Kenneth C
影响因子：
158.5
作者：
Bach, PB;Cramer, LD;Begg, CB
通讯作者：
Begg, CB
影响因子：
5.5
作者：
Davis VN;Lavender A;Bayakly R;Ray K;Moon T
通讯作者：
Moon T
影响因子：
5
作者：
Pampel, FC;Rogers, RG
通讯作者：
Rogers, RG