Therapeutic Potential of Senolytics in Cardiovascular Disease.
Therapeutic Potential of Senolytics in Cardiovascular Disease.
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DOI：
10.1007/s10557-020-07075-w
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Richardson GD
中科院分区：
文献类型：
--
作者：
Dookun E;Passos JF;Arthur HM;Richardson GD
老龄化是心血管健康受损的最大风险因素，在65岁以上的人群中，心血管疾病是导致40%死亡的主要原因。衰老与心血管疾病（包括心力衰竭、冠状动脉疾病和心肌梗死）患病率增加有关。此外，衰老与这些疾病的预后较差有关。允许消除衰老细胞的遗传模型显示，衰老的积累有助于心血管衰老的病理生理，并通过表达促炎和促纤维化衰老相关的分泌表型促进心血管疾病的进展。这些研究的结果是努力确定能够通过诱导凋亡特异性消除衰老细胞的药理学治疗方法。这些诱导衰老细胞凋亡的化合物被称为抗衰老药物，它们改善年龄相关心血管疾病的潜力是本综述的重点。
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction. Furthermore, ageing is associated with a poorer prognosis to these diseases. Genetic models allowing the elimination of senescent cells revealed that an accumulation of senescence contributes to the pathophysiology of cardiovascular ageing and promotes the progression of cardiovascular disease through the expression of a proinflammatory and profibrotic senescence-associated secretory phenotype. These studies have resulted in an effort to identify pharmacological therapeutics that enable the specific elimination of senescent cells through apoptosis induction. These senescent cell apoptosis-inducing compounds are termed senolytics and their potential to ameliorate age-associated cardiovascular disease is the focus of this review.
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影响因子：
7.8
作者：
Bernardes de Jesus B;Schneeberger K;Vera E;Tejera A;Harley CB;Blasco MA
通讯作者：
Blasco MA
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
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van Deursen JM
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
82.9
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
通讯作者：
Mallat, Z
影响因子：
2.8
作者：
Bruening, Ansgar
通讯作者：
Bruening, Ansgar