Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI.

Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI.
复制标题

用溶解相超极化氙-129 MRI表征COPD中的气体交换。

DOI:
10.1136/thoraxjnl-2020-214924
复制
发表时间:
2021-03
期刊:
影响因子:
10
通讯作者:
Shim YM
Shim YM
中科院分区:
医学1区
文献类型:
--
作者:
Myc L;Qing K;He M;Tustison N;Lin Z;Manichaikul AW;Patrie J;Cassani J;Nunoo-Asare RN;Huang Y;Obaida Z;Tafti S;Ropp AM;Miller GW;Mata J;Altes T;Mugler J;Shim YM

文献摘要

参考文献

被引文献

相似文献

为了研究超极化氙-129 MRI(HXeMRI)是否能够在慢性阻塞性肺疾病(COPD)中实现弥散能力限制的区域和生理分辨率,我们评估了34名COPD受试者和11名健康志愿者。我们报告了HXeMRI定量的气流异常与1秒用力呼气量百分比、HXeMRI向红细胞的气体转移能力与一氧化碳弥散能力(%DLCO)、HXeMRI向氚的气体转移能力与多探测器胸部CT定量的肺气肿百分比之间的显著相关性。我们进一步证明了HXeMRI区分低%DLCO和轻微肺气肿受试者中COPD基础的不同病理的能力。
To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema.
DOI: 10.1164/rccm.201311-2006pp
发表时间: 2014-05-01
影响因子: 24.7
作者:
Vestbo, Jorgen;Agusti, Alvar;Tal-Singer, Ruth
通讯作者: Tal-Singer, Ruth
DOI: 10.1186/s12931-014-0127-9
发表时间: 2014-10-12
影响因子: 5.8
作者:
Carolan BJ;Hughes G;Morrow J;Hersh CP;O'Neal WK;Rennard S;Pillai SG;Belloni P;Cockayne DA;Comellas AP;Han M;Zemans RL;Kechris K;Bowler RP
通讯作者: Bowler RP
DOI: 10.1002/nbm.3179
发表时间: 2014-12
期刊: NMR IN BIOMEDICINE
影响因子: 2.9
作者:
Qing, Kun;Mugler, John P., III;Altes, Talissa A.;Jiang, Yun;Mata, Jaime F.;Miller, G. Wilson;Ruset, Iulian C.;Hersman, F. William;Ruppert, Kai
通讯作者: Ruppert, Kai
DOI: 10.1016/j.bbrc.2011.09.006
发表时间: 2011-10-07
影响因子: 3.1
作者:
Paige, Mikell;Burdick, Marie D.;Shim, Y. Michael
通讯作者: Shim, Y. Michael
DOI: 10.1002/jmri.22738
发表时间: 2011-10-01
影响因子: 4.4
作者:
Tustison, Nicholas J.;Avants, Brian B.;Gee, James C.
通讯作者: Gee, James C.