Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI.
Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI.
复制标题
用溶解相超极化氙-129 MRI表征COPD中的气体交换。
DOI:
10.1136/thoraxjnl-2020-214924
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发表时间:
2021-03
期刊:
影响因子:
10
通讯作者:
Shim YM
中科院分区:
文献类型:
--
作者:
Myc L;Qing K;He M;Tustison N;Lin Z;Manichaikul AW;Patrie J;Cassani J;Nunoo-Asare RN;Huang Y;Obaida Z;Tafti S;Ropp AM;Miller GW;Mata J;Altes T;Mugler J;Shim YM
To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema.
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DOI:
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发表时间:
2014-05-01
影响因子:
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发表时间:
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