Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI.
Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI.
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DOI：
10.1002/nbm.3179
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发表时间：
2014-12
影响因子：
2.9
通讯作者：
Ruppert, Kai
中科院分区：
文献类型：
--
作者：
Qing, Kun;Mugler, John P., III;Altes, Talissa A.;Jiang, Yun;Mata, Jaime F.;Miller, G. Wilson;Ruset, Iulian C.;Hersman, F. William;Ruppert, Kai
利用超极化氙 - 129的磁共振波谱和成像在评估人体肺部最重要的功能——气体交换方面显示出巨大潜力。特别是，化学位移饱和恢复（CSSR）氙 - 129波谱通过表征气体交换的动态过程，为整个肺部提供了重要的生理信息，而溶解相氙 - 129成像则捕捉到了肺组织和血液吸收气体的时间平均区域分布。在此，我们介绍了在总共45名受试者（23名健康者、13名慢性阻塞性肺疾病（COPD）患者和9名哮喘患者）中使用CSSR波谱和溶解相成像评估肺功能的最新进展。从CSSR数据采集来看，COPD患者的红细胞与组织/血浆（RBC - to - TP）比值低于健康受试者的平均值（p < 0.001），但与健康受试者相比，间隔壁厚度明显更高（p < 0.005）；哮喘患者的RBC - to - TP比值偏离健康受试者平均值2个标准差（更高或更低），尽管整个研究组的平均比值没有统计学上的显著差异。同样，从3D溶解相（DP）成像数据采集来看，我们发现COPD患者的所有测量比值（组织/血浆与气体相（TP - to - GP）、红细胞与气体相（RBC - to - GP）、红细胞与组织/血浆（RBC - to - TP））均低于健康受试者（所有比值p < 0.05），而哮喘患者的这些比值在个体之间差异很大。尽管是在不同的肺充气水平下进行的，但CSSR和3D溶解相成像所测量的RBC - to - TP比值彼此相当一致，平均差异为0.037（3D溶解相成像的比值更大）。在10名受试者中，从3D溶解相成像数据采集获得的RBC - to - GP比值也与通过肺功能测试测量的一氧化碳弥散量/肺泡容积（DLCO/Va）比值高度相关（R = 0.91）
Magnetic-resonance spectroscopy and imaging using hyperpolarized xenon-129 show great potential for evaluation of the most important function of the human lung -- gas exchange. In particular, Chemical Shift Saturation Recovery (CSSR) xenon-129 spectroscopy provides important physiological information for the lung as a whole by characterizing the dynamic process of gas exchange, while dissolved-phase xenon-129 imaging captures the time-averaged regional distribution of gas uptake by lung tissue and blood. Herein, we present recent advances in assessing lung function using CSSR spectroscopy and dissolved-phase imaging in a total of 45 subjects (23 healthy, 13 chronic obstructive pulmonary disease (COPD) and 9 asthma). From CSSR acquisitions, the COPD subjects showed red blood cell to tissue/plasma (RBC-to-TP) ratios below the average for the healthy subjects (p<0.001), but significantly higher septal wall thicknesses, as compared with the healthy subjects (p<0.005); the RBC-to-TP ratios for the asthmatics fell outside 2 standard deviations (either higher or lower) from the mean of the healthy subjects although there was no statistically significant difference for the average ratio of the study group as a whole. Similarly, from the 3D DP imaging acquisitions, we found all the ratios (TP-to-GP, RBC-to-GP, RBC-to-TP) measured in the COPD subjects were lower than those from the healthy subjects (p<0.05 for all ratios), while these ratios in the asthmatics differed considerably between subjects. Despite having been performed at different lung inflation levels, the RBC-to-TP ratios measured by CSSR and 3D DP imaging were fairly consistent with each other, with a mean difference of 0.037 (ratios from 3D DP imaging larger). In ten subjects the RBC-to-GP ratios obtained from the 3D DP imaging acquisitions were also highly correlated with their DLCO/Va ratios measured by pulmonary function testing (R=0.91).
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影响因子：
4.4
作者：
Mugler, John P.;Altes, Talissa A.
通讯作者：
Altes, Talissa A.
影响因子：
7.3
作者：
ABRAHAM, MH;KAMLET, MJ;WEATHERSBY, PK
通讯作者：
WEATHERSBY, PK
影响因子：
3.3
作者：
Mugler, JP;Driehuys, B;Wagshul, ME
通讯作者：
Wagshul, ME
影响因子：
19.7
作者：
Driehuys, Bastiaan;Martinez-Jimenez, Santiago;McAdams, H. Page
通讯作者：
McAdams, H. Page
DOI：
10.1073/pnas.1011912107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Mugler, John P., III;Altes, Talissa A.;Ruppert, Kai
通讯作者：
Ruppert, Kai