Eating for hunger or pleasure: a Serotonin Model.
Eating for hunger or pleasure: a Serotonin Model.
复制标题
吃饥饿或愉悦的饮食：一种5-羟色胺模型。
DOI：
10.1093/jmcb/mjab055
复制
发表时间：
2021-12-06
影响因子：
5.5
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Yan Z;He Y;Cai X;Shu G;Xu Y
Obesity, resulting from an imbalance between energy intake and expenditure, represents a major health crisis to our society, due to its alarmingly high prevalence and comorbidities, including diabetes, cardiovascular diseases, cancer, and COVID-19. Better understanding the neurobiological mechanisms for feeding behavior is essential for developing rational strategies to combat obesity and related comorbidities. Agouti-related peptide (AgRP) neurons located in the arcuate nucleus of the hypothalamus (ARH) have received perhaps the most attention as a master regulator of feeding behavior. It is well known that AgRP neurons are regulated by multiple hormones that reflect the body’s energy storage or nutritional state, eg, leptin, insulin, ghrelin, and asprosin (Yang and Xu, 2020). AgRP neurons are activated in a caloriedeficient state (Takahashi and Cone, 2005; Yang et al., 2011; Liu et al., 2012), and activations of AgRP neurons can drive eating (Aponte et al., 2011; Krashes et al., 2011). Together, these findings support a physiological feedback pathway that regulates feeding: a calorie-deficient state (eg hunger) activates AgRP neurons, which in turn drive eating. However, this ‘AgRP model’faces a challenge, as recent in vivo recordings revealed that AgRP neurons decrease their activities dramatically within a few seconds after feeding starts, or even without the food actually being consumed (Betley et al., 2015; Chen et al., 2015; Mandelblat-Cerf et al., 2015). This rapid diminishment of AgRP neuron activity (Figure 1A) raises a question regarding how feeding behavior, which usually lasts for minutes to hours, is sustained. Based on our observations reported in a recent Molecular Psychiatry article (He et al., 2021), we propose an alternative ‘Serotonin Model’, which provides physiological feedback signals for feeding control.The brain serotonin, a neurotransmitter also known as 5-hydroxytryptamine (5-HT), is mainly synthesized by neurons in the midbrain dorsal Raphe nucleus (DRN). We demonstrated that the activation of these 5-HT DRN neurons can inhibit eating (He et al., 2021). Importantly, using the in vivo recordings, we found that 5-HTDRN neurons gradually increase their activities during the 2-h feeding period (Figure 1A). In sharp contrast to the rapid and sustained inhibition of AgRP neurons, the activation of 5-HTDRN neurons occurs in a gradual and slow fashion (He et al., 2021). Importantly, the
登录
查看更多内容
影响因子：
15.9
作者：
Krashes, Michael J.;Koda, Shuichi;Lowell, Bradford B.
通讯作者：
Lowell, Bradford B.
食物的感官检测快速调节弧形喂食电路。
影响因子：
64.5
作者：
Chen Y;Lin YC;Kuo TW;Knight ZA
通讯作者：
Knight ZA
影响因子：
5.5
作者：
Yang Y;Xu Y
通讯作者：
Xu Y
影响因子：
29
作者：
Rossi MA;Stuber GD
通讯作者：
Stuber GD
影响因子：
64.5
作者：
Yang, Yunlei;Atasoy, Deniz;Sternson, Scott M.
通讯作者：
Sternson, Scott M.