Osteoporosis and cancer.
Osteoporosis and cancer.
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DOI：
10.1007/s11914-013-0154-3
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发表时间：
2013-09
影响因子：
4.3
通讯作者：
Drake, Matthew T.
中科院分区：
文献类型：
--
作者：
Drake, Matthew T.
关键词：
癌症是骨质流失和骨折的主要危险因素。这是由于癌细胞对骨骼的直接影响和癌症特异性治疗对骨细胞的有害影响。许多癌症存活率的显著提高意味着限制骨质流失和降低骨折风险的策略必须纳入几乎所有癌症患者的护理计划中。迄今为止，绝大多数的努力都集中在乳腺癌和前列腺癌患者的骨质流失上，而对其他恶性肿瘤的研究相对较少。抗骨吸收疗法已被证明在限制癌症患者骨质流失方面几乎普遍有效，尽管很少有研究足够有力地将骨折作为主要终点，而且患者经常既没有根据已发表的指南进行识别也没有进行治疗。限制跌倒的非药物方法，特别是老年患者，也可能是大多数癌症患者重要的辅助措施。
Cancer is a major risk factor for bone loss and fractures. This is due both to direct effects of cancer cells on the skeleton and to deleterious effects of cancer-specific therapies on bone cells. Marked improvements in survival for many cancers mean that strategies to limit bone loss and reduce fracture risk must be incorporated into the care plans for nearly all patients with cancer. The vast majority of effort thus far has focused on bone loss in patients with breast and prostate cancers, with comparatively few studies in other malignancies. Anti-resorptive therapies have proven nearly universally effective for limiting bone loss in cancer patients, although few studies have been powered sufficiently to include fractures as primary endpoints, and patients are frequently neither identified nor treated according to published guidelines. Non-pharmacologic approaches to limit falls, particularly in elderly patients, are also likely important adjunctive measures for most cancer patients.
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DOI：
10.1016/j.ecl.2012.05.001
发表时间：
2012-09
影响因子：
4.5
作者：
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影响因子：
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