Male osteoporosis.

Male osteoporosis.
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DOI:
10.1016/j.ecl.2012.05.001
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发表时间:
2012-09
影响因子:
4.5
通讯作者:
Khosla, Sundeep
Khosla, Sundeep
中科院分区:
医学2区
文献类型:
--
作者:
Drake, Matthew T.;Khosla, Sundeep

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骨质疏松症现在被认为是对老年男性健康的主要威胁。发病率和死亡率,特别是髋部骨折后的发病率和死亡率很高。骨小梁丢失在成年早期就开始了,而皮质骨的丢失似乎只发生在中年以后。生物可利用雌二醇水平的下降在男性年龄相关性骨丢失中起着不可或缺的作用。对于骨折风险增加的男性,药理学和支持性护理干预对于最佳护理都很重要。
Osteoporosis is now recognized as a major threat to health in aging men. Morbidity and mortality, particularly following hip fracture, are substantial. Whereas trabecular bone loss starts in early adulthood, loss of cortical bone only appears to occur from mid-life onwards. Declining bioavailable estradiol levels play an integral role in male age-associated bone loss. Both pharmacologic and supportive care interventions are important for optimal care in men at increased fracture risk.
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