Influence of previous Zika virus infection on acute dengue episode.
Influence of previous Zika virus infection on acute dengue episode.
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DOI：
10.1371/journal.pntd.0011710
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发表时间：
2023-11
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
黄病毒在热带地区的共循环导致了这样一种假设，即由先前的登革热感染产生的免疫力可以在随后的异源血清型感染中促进严重的疾病结果。这项研究调查了先前寨卡病毒感染产生的抗体对登革热感染临床结果的影响。我们招募了1，043名实验室确诊的登革热患者，并调查了他们之前感染寨卡病毒或登革热的情况。严重形式的登革热疾病在先前感染寨卡病毒的患者中更常见，但在先前暴露于登革热的患者中则不然。我们的研究结果表明，先前的寨卡病毒感染可能是随后严重登革热疾病的风险因素，但我们没有发现抗体依赖性增强（更高的病毒滴度或促炎细胞因子过度表达）导致随后登革热感染恶化的证据。虽然登革热是世界上已知多年的疾病，并已影响到几个大陆，但有些方面仍不清楚。其中之一是关于可能影响严重疾病发展的可能因素。关于先前登革热发作的影响已经讨论了很多，但是其他黄病毒在登革热已经流行的地区的全球传播引起了人们对其他登革热血清型的兴趣。从这个意义上说，最近寨卡病毒的传播已经成为一个令人感兴趣的因素。在这项研究中，先前的寨卡病毒感染与随后的登革热中更严重形式的更高频率相关。初步研究结果并没有表明这种机制与继发性登革热中触发的机制相同，称为抗体依赖性增强。这些发现刺激了进一步的研究，可以了解发病机制中涉及的潜在机制。
The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection. We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue. Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection. Although dengue is a disease known for years in the world and has been affecting several continents, some aspects remain unclear. One of them is about the possible factors that may influence the development of severe forms of the disease. Much has been discussed about the influence of a previous dengue episode, but the global spreading of other flaviviruses to areas where dengue was already circulating has aroused interest regarding a role like the other dengue serotypes. In this sense, the recent spreading of the Zika virus has become a factor of interest. In this study, the prior Zika virus infection was associated with a higher frequency of more severe forms in subsequent dengue. Preliminary findings did not suggest that the mechanism is the same one triggered in secondary dengue, known as antibody-dependent enhancement. These findings are a stimulus to develop further research that can understand the potential mechanisms involved in the pathogenesis.
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影响因子：
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Bonheur AN;Thomas S;Soshnick SH;McGibbon E;Dupuis AP 2nd;Hull R;Slavinski S;Del Rosso PE;Weiss D;Hunt DT;McCabe ME;Dean AB;Folkerth R;Laib AM;Wong SJ
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