Pharmacogenomics and individualized medicine: translating science into practice.
Pharmacogenomics and individualized medicine: translating science into practice.
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DOI：
10.1038/clpt.2012.120
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发表时间：
2012-10
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
对基因和药物的研究促进了我们对个体药物反应的遗传基础的理解。药物基因组学的目的是制定患者个性化治疗策略，通过了解人类基因组变异性及其对药物反应的影响来优化结果。药物基因组学研究本质上是转化的，范围从发现基因型-表型关系到提供临床影响证据的临床试验。药物基因组学的进展为个体患者的后续临床应用提供了巨大的潜力;然而，药物基因组学研究成果转化为临床实践的速度一直很慢。药物基因组学成功临床实施的关键组成部分将包括药物基因组学测试结果的一致性解释，基于测试结果的处方临床指南的可用性，以及基于知识的决策支持系统。
Research on genes and medications has advanced our understanding of the genetic basis of individual drug responses. The aim of pharmacogenomics is to develop strategies for individualizing therapy for patients, to optimize outcome through knowledge of human genome variability and its influence on drug response. Pharmacogenomics research is translational in nature and ranges from discovery of genotype-phenotype relationships to clinical trials which provide proof of clinical impact. Advances in pharmacogenomics offer significant potential for subsequent clinical application in individual patients; however, the translation of pharmacogenomics research findings into clinical practice has been slow. Key components to successful clinical implementation of pharmacogenomics will include consistent interpretation of pharmacogenomic test results, availability of clinical guidelines for prescribing based on test results, and knowledge-based decision support systems.
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影响因子：
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