Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models.
Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models.
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DOI：
10.1093/humrep/dep438
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Shao R
中科院分区：
文献类型：
--
作者：
Shao R
异位妊娠是一个全球性的健康问题，可能危及生命，在西方世界约占所有妊娠的1.5-2%;然而，输卵管异位妊娠发生和发展的确切机制尚不清楚。输卵管异常和功能障碍，如收缩力改变或纤毛活动异常，被认为是导致输卵管异位妊娠的原因。为了阐明输卵管转运过程的细胞和分子机制，已经开发了几种敲除（KO）小鼠模型。本文综述了从caspase-1，大麻素受体和Dicer 1基因敲除小鼠输卵管的研究中所学到的。通过进一步研究这些KO小鼠模型，我们对人类输卵管异位妊娠机制的理解可能会得到加强。
Ectopic pregnancy, a worldwide health problem, is potentially life-threatening and occurs in approximately 1.5–2% of all pregnancies in the western world; however, the precise mechanisms underlying the initiation and development of tubal ectopic pregnancy are unknown. Tubal abnormalities and dysfunction, such as altered contractility or abnormal ciliary activity, have been speculated to lead to tubal ectopic pregnancy. To elucidate the cellular and molecular mechanisms of the tubal transport process, several knockout (KO) mouse models have been developed. This review summarizes what has been learned from studies of the Fallopian tube in caspase-1, cannabinoid receptor and Dicer1 KO mice. Our understanding of the mechanisms which contribute to tubal ectopic pregnancy in humans may be enhanced through further study of these KO mouse models.
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影响因子：
14.9
作者：
Bhat-Nakshatri P;Wang G;Collins NR;Thomson MJ;Geistlinger TR;Carroll JS;Brown M;Hammond S;Srour EF;Liu Y;Nakshatri H
通讯作者：
Nakshatri H
影响因子：
7.2
作者：
Van den Eeden, SK;Shan, J;Glasser, M
通讯作者：
Glasser, M
DOI：
10.1152/ajpendo.00384.2007
发表时间：
2007-11-01
影响因子：
5.1
作者：
Shao, Ruijin;Egecioglu, Emil;Billig, Hakan
通讯作者：
Billig, Hakan
影响因子：
6.1
作者：
Wanggren, K.;Stavreus-Evers, A.;Gemzell-Danielsson, K.
通讯作者：
Gemzell-Danielsson, K.
影响因子：
3.7
作者：
Wang H;Xie H;Dey SK
通讯作者：
Dey SK