Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19.
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19.
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DOI：
10.26508/lsa.202101180
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发表时间：
2021-11
影响因子：
4.4
通讯作者：
Rodriguez A
中科院分区：
文献类型：
--
作者：
Gomes C;Zuniga M;Crotty KA;Qian K;Tovar NC;Lin LH;Argyropoulos KV;Clancy R;Izmirly P;Buyon J;Lee DC;Yasnot-Acosta MF;Li H;Cotzia P;Rodriguez A
新冠肺炎可以诱导高水平的自身免疫抗脱氧核糖核酸抗体和抗磷脂酰丝氨酸抗体，一些患者入院时会检测到这些抗体，并预测未来严重疾病的发展。在新冠肺炎患者中观察到高水平的自身免疫抗体，但其对疾病严重程度和临床表现的具体作用仍不清楚。我们对115例不同严重程度的新冠肺炎住院患者进行了回顾性研究，以分析针对常见抗原：红细胞裂解物、磷脂酰丝氨酸和脱氧核糖核酸的自身免疫抗体的产生情况。在很大比例(高达36%)的患者中观察到高水平的抗红细胞裂解物自身抗体。入院时检测的抗DNA抗体和抗PS抗体与严重疾病的晚期发展密切相关，阳性预测值分别为85.7%和92.8%。两种自身抗体中至少有一种阳性的患者占重症病例总数的24%。统计分析表明，抗DNA抗体与细胞损伤、凝血、中性粒细胞水平和红细胞大小的标志物之间存在很强的相关性。抗脱氧核糖核酸和抗PS自身抗体可能在新冠肺炎的发病机制中起重要作用，可作为预测疾病严重程度和特定临床表现的生物标志物。
COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease. High levels of autoimmune antibodies are observed in COVID-19 patients but their specific contribution to disease severity and clinical manifestations remains poorly understood. We performed a retrospective study of 115 COVID-19 hospitalized patients with different degrees of severity to analyze the generation of autoimmune antibodies to common antigens: a lysate of erythrocytes, the lipid phosphatidylserine (PS) and DNA. High levels of IgG autoantibodies against erythrocyte lysates were observed in a large percentage (up to 36%) of patients. Anti-DNA and anti-PS antibodies determined upon hospital admission correlated strongly with later development of severe disease, showing a positive predictive value of 85.7% and 92.8%, respectively. Patients with positive values for at least one of the two autoantibodies accounted for 24% of total severe cases. Statistical analysis identified strong correlations between anti-DNA antibodies and markers of cell injury, coagulation, neutrophil levels and erythrocyte size. Anti-DNA and anti-PS autoantibodies may play an important role in the pathogenesis of COVID-19 and could be developed as predictive biomarkers for disease severity and specific clinical manifestations.
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危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
--
作者：
Petri, Michelle;Orbai, Ana-Maria;Alarcon, Graciela S.;Gordon, Caroline;Merrill, Joan T.;Fortin, Paul R.;Bruce, Ian N.;Isenberg, David;Wallace, Daniel J.;Nived, Ola;Sturfelt, Gunnar;Ramsey-Goldman, Rosalind;Bae, Sang-Cheol;Hanly, John G.;Sanchez-Guerrero, Jorge;Clarke, Ann;Aranow, Cynthia;Manzi, Susan;Urowitz, Murray;Gladman, Dafna;Kalunian, Kenneth;Costner, Melissa;Werth, Victoria P.;Zoma, Asad;Bernatsky, Sasha;Ruiz-Irastorza, Guillermo;Khamashta, Munther A.;Jacobsen, Soren;Buyon, Jill P.;Maddison, Peter;Dooley, Mary Anne;van vollenhoven, Ronald F.;Ginzler, Ellen;Stoll, Thomas;Peschken, Christine;Jorizzo, Joseph L.;Callen, Jeffrey P.;Lim, S. Sam;Fessler, Barri J.;Inanc, Murat;Kamen, Diane L.;Rahman, Anisur;Steinsson, Kristjan;Franks, Andrew G., Jr.;Sigler, Lisa;Hameed, Suhail;Fang, Hong;Ngoc Pham;Brey, Robin;Weisman, Michael H.;McGwin, Gerald, Jr.;Magder, Laurence S.
通讯作者：
Magder, Laurence S.
影响因子：
7.3
作者：
Ludwig RJ;Vanhoorelbeke K;Leypoldt F;Kaya Z;Bieber K;McLachlan SM;Komorowski L;Luo J;Cabral-Marques O;Hammers CM;Lindstrom JM;Lamprecht P;Fischer A;Riemekasten G;Tersteeg C;Sondermann P;Rapoport B;Wandinger KP;Probst C;El Beidaq A;Schmidt E;Verkman A;Manz RA;Nimmerjahn F
通讯作者：
Nimmerjahn F
影响因子：
5
作者：
Lippi, Giuseppe;Plebani, Mario;Henry, Brandon Michael
通讯作者：
Henry, Brandon Michael
影响因子：
13.8
作者：
Foy BH;Carlson JCT;Reinertsen E;Padros I Valls R;Pallares Lopez R;Palanques-Tost E;Mow C;Westover MB;Aguirre AD;Higgins JM
通讯作者：
Higgins JM