Regulatory mechanisms of neutrophil migration from the circulation to the airspace.
Regulatory mechanisms of neutrophil migration from the circulation to the airspace.
复制标题
中性粒细胞从循环到空域的调节机制。
DOI：
10.1007/s00018-021-03768-z
复制
发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Fessler MB
中科院分区：
文献类型：
--
作者：
Lin WC;Fessler MB
中性粒细胞是先天免疫系统中一种短命的效应白细胞，以其蛋白酶和其他降解货物而闻名，它与肺具有独特的、互惠的生理相互作用。在健康期间，大量的“边缘”中性粒细胞驻留在肺血管中，在那里它们巡逻内皮表面寻找病原体并完成它们的生命周期。在呼吸道感染时，中性粒细胞通过内皮屏障，穿过血管外肺间质，再通过呼吸道上皮进入空气腔，迅速而持续地募集，这是杀死病原体所必需的。然而，过量的中性粒细胞向肺输送会引起旁观者组织损伤，并成为几种急性和慢性肺部疾病的基础。部分由于肺毛细血管网络的独特结构，中性粒细胞遵循显微解剖通道进入远端空域，这与它浸润的其他终末器官不同。在过去的几十年里，已经确定了循环中性粒细胞向感染肺部逐步募集的几个调节机制；然而，根本问题依然存在。在这篇文章中，我们对中性粒细胞在肺生物学中的新角色、控制中性粒细胞向肺运输的分子机制、以及过去和正在进行的干预肺部疾病中肺中性粒细胞的治疗设计进行了最新的回顾和展望。
The neutrophil, a short-lived effector leukocyte of the innate immune system best known for its proteases and other degradative cargo, has unique, reciprocal physiological interactions with the lung. During health, large numbers of ‘marginated’ neutrophils reside within the pulmonary vasculature, where they patrol the endothelial surface for pathogens and complete their life cycle. Upon respiratory infection, rapid and sustained recruitment of neutrophils through the endothelial barrier, across the extravascular pulmonary interstitium, and again through the respiratory epithelium into the airspace lumen, is required for pathogen killing. Overexuberant neutrophil trafficking to the lung, however, causes bystander tissue injury and underlies several acute and chronic lung diseases. Due in part to the unique architecture of the lung’s capillary network, the neutrophil follows a microanatomic passage into the distal airspace unlike that observed in other end-organs that it infiltrates. Several of the regulatory mechanisms underlying the stepwise recruitment of circulating neutrophils to the infected lung have been defined over the past few decades; however, fundamental questions remain. In this article, we provide an updated review and perspective on emerging roles for the neutrophil in lung biology, on the molecular mechanisms that control the trafficking of neutrophils to the lung, and on past and ongoing efforts to design therapeutics to intervene upon pulmonary neutrophilia in lung disease.
登录
查看更多内容
影响因子：
16.6
作者：
Akthar S;Patel DF;Beale RC;Peiró T;Xu X;Gaggar A;Jackson PL;Blalock JE;Lloyd CM;Snelgrove RJ
通讯作者：
Snelgrove RJ
影响因子：
6
作者：
Brazil, Jennifer C.;Sumagin, Ronen;Parkos, Charles A.
通讯作者：
Parkos, Charles A.
影响因子：
8
作者：
Barnes, Jessica L.;Plank, Maximilian W.;Foster, Paul S.
通讯作者：
Foster, Paul S.
影响因子：
10
作者：
Blazquez-Prieto, Jorge;Lopez-Alonso, Ines;Albaiceta, Guillermo M.
通讯作者：
Albaiceta, Guillermo M.
影响因子：
3.1
作者：
Behzad, AR;Chu, F;Walker, DC
通讯作者：
Walker, DC