Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.
Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.
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DuP 753（一种血管紧张素 II 拮抗剂）对自发性高血压大鼠的降压作用。
DOI：
10.1161/01.hyp.15.5.459
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发表时间：
1990
期刊：
影响因子：
8.3
通讯作者：
P. B. Timmermans
中科院分区：
文献类型：
--
作者：
P. Wong;W. Price;A. Chiu;J. Duncia;D. Carini;R. Wexler;A. Johnson;P. B. Timmermans
在清醒的18-21周龄自发性高血压大鼠上，非肽类血管紧张素II受体拮抗剂DUP 753以3 mg/kg和10 mg/kg的剂量口服或以3、10和30 mg/kg的剂量静脉注射均可呈剂量依赖性地降低血压。在这些剂量下，它不会改变心率。在静脉注射10毫克/公斤时，DUP 753至少在24小时内显著降低血压，这表明降压效果持续时间较长。与Saralasin不同，DUP 753不会导致一过性血压升高。DUP 753的急性降压疗效优于卡托普利。我们的数据表明，要使卡托普利的降压效果达到与DUP 753相似的程度，需要辅以利尿剂。DUP 753没有急性利尿作用。切除双侧肾，但不能抑制前列腺素合成，取消了DUP 753的降压作用，提示DUP 753的降压作用依赖于活跃的肾素-血管紧张素系统。此外，DUP 753抑制血管紧张素II的升压反应，但不抑制去甲肾上腺素、加压素和Bay K 8644(一种钙激动剂)的反应。由于DUP 753和卡托普利均不能显著降低Wistar-京都正常血压大鼠的血压，我们的结果提示肾素-血管紧张素系统在自发性高血压大鼠的血压控制中起着重要作用。
In conscious 18-21-week-old spontaneously hypertensive rats, DuP 753, a nonpeptide angiotensin II receptor antagonist, given orally at 3 and 10 mg/kg or intravenously at 3, 10, and 30 mg/kg, reduced blood pressure dose dependently. It did not alter heart rate at these doses. At 10 mg/kg i.v., DuP 753 decreased blood pressure significantly for at least 24 hours, suggesting a long duration of the antihypertensive effect. Unlike saralasin, DuP 753 did not cause a transient increase in blood pressure. The acute antihypertensive efficacy of DuP 753 was greater than that of captopril. Our data indicate that, for captopril to reduce blood pressure to a similar extent as that of DuP 753, it would need to be supplemented by a diuretic. DuP 753 did not have an acute diuretic effect. Bilateral nephrectomy, but not inhibition of prostaglandin synthesis, abolished the antihypertensive effect of DuP 753, suggesting that the antihypertensive effect of DuP 753 is dependent on an active renin-angiotensin system. Furthermore, DuP 753 inhibited the pressor response to angiotensin II but not the responses to norepinephrine, vasopressin, and Bay K 8644 (a calcium agonist). As neither DuP 753 nor captopril decreased blood pressure acutely in Wistar-Kyoto normotensive rats, our results suggest that the renin-angiotensin system plays a significant role in the control of blood pressure in spontaneously hypertensive rats.
DOI：
--
发表时间：
1978-02
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
R. Laffan;M. E. Goldberg;J. High;T. Schaeffer;M. Waugh;B. Rubin
通讯作者：
R. Laffan;M. E. Goldberg;J. High;T. Schaeffer;M. Waugh;B. Rubin
潜在的内皮细胞肽基二肽酶（不是血管紧张素转换酶）将血管紧张素 1 转化为血管紧张素 2。
DOI：
10.1016/s0006-291x(86)80487-9
发表时间：
1986
影响因子：
3.1
作者：
Lanzillo,JJ;Dasarathy,Y;Stevens,J;Fanburg,BL
通讯作者：
Fanburg,BL