Host transcriptome response to Borrelia burgdorferi sensu lato.
Host transcriptome response to Borrelia burgdorferi sensu lato.
复制标题
宿主对广义伯氏疏螺旋体的转录组应答。
DOI：
10.1016/j.ttbdis.2020.101638
复制
发表时间：
2021-03
影响因子：
3.2
通讯作者：
Brissette CA
中科院分区：
文献类型：
--
作者：
Thompson D;Watt JA;Brissette CA
宿主对感染的免疫应答是先天性和适应性免疫细胞的良好协调系统，其协同工作以防止病原体的定殖和传播。虽然这通常导致有益的结果和疾病发病机制的抑制，但莱姆疏螺旋体病细菌，广义伯氏疏螺旋体，可以引发导致有害状态的免疫特征。作为B。布格多费里公司没有产生已知的毒素，这表明宿主的免疫和炎症反应是导致症状表现的原因，包括流感样症状、肌肉骨骼疼痛和认知障碍。在过去的几年中，已经看到了大量增加的使用微阵列和测序技术来研究由B诱导的转录组反应。burgdorferi s.l.，从而使研究人员能够确定莱姆病的病理生理学基础的关键因素和途径。在这篇综述中，我们提出了几项研究中细菌诱导的主要宿主转录结果，并讨论了宿主炎症和免疫反应的总体主题，以及它如何影响莱姆病的病理学。
The host immune response to infection is a well-coordinated system of innate and adaptive immune cells working in concert to prevent the colonization and dissemination of a pathogen. While this typically leads to a beneficial outcome and the suppression of disease pathogenesis, the Lyme borreliosis bacterium, Borrelia burgdorferi sensu lato, can elicit an immune profile that leads to a deleterious state. As B. burgdorferi s.l. produces no known toxins, it is suggested that the immune and inflammatory response of the host are responsible for the manifestation of symptoms, including flu-like symptoms, musculoskeletal pain, and cognitive disorders. The past several years has seen a substantial increase in the use of microarray and sequencing technologies to investigate the transcriptome response induced by B. burgdorferi s.l., thus enabling researchers to identify key factors and pathways underlying the pathophysiology of Lyme borreliosis. In this review we present the major host transcriptional outcomes induced by the bacterium across several studies and discuss the overarching theme of the host inflammatory and immune response, and how it influences the pathology of Lyme borreliosis.
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