HIV Proteins in Normal Human Placentae
HIV Proteins in Normal Human Placentae
复制标题
正常人胎盘中的 HIV 蛋白
DOI：
--
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发表时间：
1991
影响因子：
3.6
通讯作者：
C. Labarrere
中科院分区：
文献类型：
--
作者：
W. Faulk;C. Labarrere
ABSTRACT: Cryostat sections of human normal term placentae were studied for evidence of immunopathology by using antibodies to lymphocytes, macrophages, platelets, and coagulation factors. Areas of so‐called chronic villitis of unestablished etiology were identified in all placentae. The same tissues were examined for HIV protein antigens gp120, p17, p24, and gp41. No evidence for gp41 was found. Antigens gp120 and p17 were identified in normal chorionic villi in vimentin‐positive fibroblast‐like cells and in endothelium, respectively. Antigen p24 was localized to HLA‐DR positive cells that morphologically resembled macrophages in areas of villitis. The distribution of gp120 and p17 was similar to that observed for tissue factor. These findings prompted speculation that retroviral proto‐oncogenes that are known to encode for certain placental receptors could be involved in the presentation of tissue factor, and that gp120 may be a hitherto unrecognized immunobiological mechanism for the blockade of CD4 on maternal lymphocytes if and when such cells gain entrance to chorionic villi.
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在没有病毒感染的情况下，HIV-1 GP120 介导的免疫抑制和淋巴细胞破坏。
DOI：
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发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Weinhold,KJ;Lyerly,HK;Stanley,SD;Austin,AA;Matthews,TJ;Bolognesi,DP
通讯作者：
Bolognesi,DP
组织因子：人类胎盘细胞类型的鉴定和表征。
影响因子：
20.3
作者：
Faulk,WP;Labarrere,CA;Carson,SD
通讯作者：
Carson,SD
影响因子：
56.9
作者：
DOOLITTLE, RF;HUNKAPILLER, MW;ANTONIADES, HN
通讯作者：
ANTONIADES, HN
HIV 包膜蛋白 gp120 对 CD4 T 细胞功能的抑制。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Diamond,DC;Sleckman,BP;Gregory,T;Lasky,LA;Greenstein,JL;Burakoff,SJ
通讯作者：
Burakoff,SJ
人胎盘合体滋养层 Mr 75,000 多肽由基于克隆人内源逆转录病毒 DNA 序列的合成肽抗体定义。
DOI：
10.1073/pnas.81.19.6197
发表时间：
1984
影响因子：
11.1
作者：
Suni,J;Närvänen,A;Wahlström,T;Aho,M;Pakkanen,R;Vaheri,A;Copeland,T;Cohen,M;Oroszlan,S
通讯作者：
Oroszlan,S