Neural correlates of the interactive relationship between memory deficits and depressive symptoms in nondemented elderly: resting fMRI study.
Neural correlates of the interactive relationship between memory deficits and depressive symptoms in nondemented elderly: resting fMRI study.
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DOI：
10.1016/j.bbr.2011.01.008
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发表时间：
2011-06-01
影响因子：
2.7
通讯作者：
Li, Shi-Jiang
中科院分区：
文献类型：
--
作者：
Goveas, Joseph;Xie, Chunming;Wu, Zhilin;Ward, B. Douglas;Li, Wenjun;Franczak, Malgorzata B.;Jones, Jennifer L.;Antuono, Piero G.;Yang, Zheng;Li, Shi-Jiang
关键词：
前瞻性研究表明，老年人抑郁症状与认知障碍之间存在关联。然而，人们对这种关系的神经关联知之甚少。我们的目的是检查记忆缺陷和抑郁症状的相互作用是否存在于与记忆相关的功能网络中，在非痴呆的老年受试者中。本研究选取15例健忘轻度认知障碍（aMCI）患者和20例年龄匹配的正常老年人（CN）为研究对象。静息状态功能连通性MRI （R-fMRI）测量两组海马功能连通性（HFC）的变化。在调整了年龄和群体效应后，对海马网络强度与Rey听觉言语学习测试延迟回忆和老年抑郁量表评分进行体素线性回归分析。较差的记忆表现与特定额叶和默认模式网络（DMN）结构的HFC正相关连通性下降有关。较差的记忆表现还与双侧下顶叶和右背外侧前额叶皮层中反相关的HFC连通性下降有关。相反，更严重的抑郁症状与几个额叶和DMN区域的HFC连通性增加有关。抑郁症状和记忆功能对额叶、颞叶和PCC结构的HFC有交互影响。我们的研究结果表明，R-fMRI技术可用于检查老年人群中记忆缺陷和抑郁症状共存的功能性神经网络的变化。
Prospective studies have shown an association between depressive symptoms and cognitive impairment among older adults. However, the neural correlates of this relationship are poorly understood. Our aim was to examine whether interactive effects of memory deficits and depressive symptoms are present in the memory-associated functional networks, in nondemented elderly subjects. Fifteen subjects with amnestic mild cognitive impairment (aMCI) and 20 age-matched normal (CN) elderly subjects participated in this cross-sectional study. Resting-state functional connectivity MRI (R-fMRI) measured the hippocampal functional connectivity (HFC) alterations between the two groups. Voxelwise linear regression analysis was performed to correlate hippocampal network strength with the Rey Auditory Verbal Learning Test delayed recall and the Geriatric Depression Scale scores, after adjusting for age and group effects. Poorer memory performance was associated with decreased positively correlated HFC connectivity in the specific frontal lobe and default mode network (DMN) structures. Poorer memory performance also was associated with decreased anticorrelated HFC connectivity in the bilateral inferior parietal and right dorsolateral prefrontal cortices. In contrast, greater depressive symptom severity was associated with increased HFC connectivity in several frontal lobes and DMN regions. Depressive symptoms and memory functions had interactive effects on the HFC, in the frontal, temporal, and PCC structures. Our findings suggest that the R-fMRI technique can be used to examine the changes in functional neural networks where memory deficits and depressive symptoms coexist in the geriatric population.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
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作者：
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影响因子：
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