Bronchoconstriction-triggered Cough Is Impaired in Typical Asthmatics
Bronchoconstriction-triggered Cough Is Impaired in Typical Asthmatics
复制标题
典型哮喘患者的支气管收缩引发的咳嗽受到损害
DOI：
10.3109/02770900903362650
复制
发表时间：
2010
影响因子：
1.9
通讯作者：
N. Katayama
中科院分区：
文献类型：
--
作者：
N. Ohkura;M. Fujimura;A. Tokuda;Y. Nakade;M. Nishitsuji;M. Abo;N. Katayama
背景和目标。咳嗽是一种基本的先天保护行为，即使是健康的个体也会经历。支气管收缩引起咳嗽的机制尚不清楚。本研究旨在探讨典型哮喘患者和正常人吸入乙酰甲胆碱（Mch）引起的支气管收缩与咳嗽的关系。方法.本文测定了15例典型哮喘患者和20例正常人的支气管对Mch的反应性，并计数了Mch引起的咳嗽次数。结果正常人吸入1秒用力呼气量（FEV 1）减少20%以上的Mch（PC_（20）-FEV 1）后，咳嗽次数为22.5次/32 min，范围为3.3 ~ 45次。相反，在典型哮喘患者中几乎不引起咳嗽（咳嗽的中位数：2/32分钟，范围：0-4）。结论.虽然典型的哮喘患者气道反应性增加，但他们对支气管收缩的咳嗽反应受损。
Background and objective. Cough is an essential innate protective behavior, which is experienced by even healthy individuals. The mechanism of cough triggered by bronchoconstriction is not yet clear. The aim of this study was to investigate the relation between bronchoconstriction and cough caused by methacholine (Mch) inhalation in typical asthmatics and normal healthy subjects. Methods. We measured bronchial responsiveness to Mch and counted the number of coughs induced by Mch inhalation in 15 typical asthmatics and 20 normal subjects. Results. After inhalation of Mch at the concentration causing 20% or more decrease in forced expiratory volume in 1 second (FEV1) (PC20-FEV1), coughs were provoked in normal subjects (number of cough: 22.5/32 min, range: 3.3–45). Conversely, coughs were hardly provoked in typical asthmatics (median number of cough: 2/32 min, range: 0–4). Conclusions. Although typical asthmatics have increased airway responsiveness, their cough response to bronchoconstriction is impaired.
DOI：
10.1186/1745-9974-5-3
发表时间：
2009-03-09
期刊：
Cough (London, England)
影响因子：
--
作者：
Matsumoto H;Niimi A;Takemura M;Ueda T;Yamaguchi M;Matsuoka H;Jinnai M;Chin K;Mishima M
通讯作者：
Mishima M
DOI：
10.1186/1745-9974-3-2
发表时间：
2007-01-12
期刊：
Cough (London, England)
影响因子：
--
作者：
Ishiura Y;Fujimura M;Nobata K;Oribe Y;Abo M;Myou S
通讯作者：
Myou S
影响因子：
10
作者：
Fujimura, M;Ogawa, H;Nishi, K
通讯作者：
Nishi, K