Macrophage oxidative burst and related cytotoxicity. I. Differential activation by tumor‐promoting and non‐tumor‐promoting phorbol esters
Macrophage oxidative burst and related cytotoxicity. I. Differential activation by tumor‐promoting and non‐tumor‐promoting phorbol esters
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巨噬细胞氧化爆发和相关的细胞毒性 I. 促进肿瘤和非肿瘤促进佛波酯的差异激活。
DOI：
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发表时间：
1984
影响因子：
6.4
通讯作者：
Ita Geva
中科院分区：
文献类型：
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作者：
Y. Keisari;E. Flescher;Ita Geva
小鼠腹腔巨噬细胞在用肿瘤促进剂12-O-十四烷酰基-佛波醇13-乙酸酯（TPA）刺激后引发氧化爆发（OB）反应。在这项研究中，我们比较了佛波醇酯衍生物的OB刺激能力，结构上与TPA相关，其促肿瘤活性不同。测试了非促肿瘤衍生物，如佛波醇13-乙酸酯、佛波醇12-肉豆蔻酸酯、TPA-2-O-醛和4-O-甲基TPA。这些试剂刺激巨噬细胞产生OB产物，如O−2和H2 O2，但刺激所需的量比引发类似反应所需的TPA量高1,000倍。还观察到，在相同的数量级，上述衍生物在使巨噬细胞对红细胞溶解方面比TPA效率低。另一种强的肿瘤促进剂，teleocidin，已被发现在激活巨噬细胞OB和相关活动中与TPA一样有效。
Mouse peritoneal macrophages elicit an oxidative burst (OB) response upon stimulation with the tumor promoter 12‐O‐tetradecanoyl‐phorbol 13‐acetate (TPA). In this study we compare the OB‐stimulating capacity of phorbol ester derivatives, structurally related to TPA, which differ in their tumor‐promoting activity. Non‐tumor‐promoting derivatives such as phorbol 13‐acetate, phorbol 12‐myristate, TPA‐2‐O‐aldehyde and 4‐O‐methyl TPA were tested. These reagents stimulate macrophages to generate OB products such as O−2 and H2O2, yet the amounts required for stimulation are 1,000 times higher than the amounts of TPA required to elicit a comparable response. It has also been observed that, in the same order of magnitude, the above‐mentioned derivatives are less efficient than TPA in rendering macrophages cytolytic toward erythrocytes. Another strong tumor promoter tested, teleocidin, has been found to be as potent as TPA in the activation of macrophage OB and in related activities.
肿瘤促进剂刺激人多形核白细胞超氧阴离子自由基的产生。
影响因子：
9.7
作者：
Goldstein,BD;Witz,G;Amoruso,M;Stone,DS;Troll,W
通讯作者：
Troll,W
DOI：
10.1073/pnas.80.1.36
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
NIEDEL, JE;KUHN, LJ;VANDENBARK, GR
通讯作者：
VANDENBARK, GR