Antitumor Activity of Liposomal Cis-Bis N-Decyl-lminodiacetato-1, 2-Diaminocyclohexane-Platinum (II) Against L1210 Leukemia and Metastases of M5076 Murine Reticulosarcoma
Antitumor Activity of Liposomal Cis-Bis N-Decyl-lminodiacetato-1, 2-Diaminocyclohexane-Platinum (II) Against L1210 Leukemia and Metastases of M5076 Murine Reticulosarcoma
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脂质体顺-双 N-癸基-亚氨基二乙酸-1, 2-二氨基环己烷-铂 (II) 对 L1210 白血病和 M5076 鼠网状肉瘤转移的抗肿瘤活性
DOI：
10.3109/08982108809035979
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发表时间：
1988
影响因子：
4.4
通讯作者：
R. Perez
中科院分区：
文献类型：
--
作者：
J. Lautersztain;A. Khokhar;R. Perez
我们研究了脂质体包裹的cis-bis-N-decyl-iminodiacetato-1，2-diaminocyclohexane-platinum(II)(L-N-decyl-IDP)in小鼠实验性肿瘤转移模型的抗肿瘤作用。将脂质体制剂与游离药物混悬液(F-N-Decyl-IDP)进行比较。在L1210白血病模型中，单次IP注射游离药物和脂质体药物的最大耐受量(MTD)是同样有效的(%T/C175)。然而，游离药物在MTD的三重ip注射方案中更有效(F-N-decyl-idp为%T/C500，而L-N-decyl-idp为300)，6只动物中有2只被游离药物治愈。在静脉(Iv)L1210白血病模型中，MTD处一次静脉注射对游离药物无效，对脂质体制剂仅轻微有效(F-N-Decly-Idp的%T/C112与L-N-Decyl-Idp的125)。在MTD的三次静脉注射中，F-N-Decyl-Idp仅有轻微的有效(%T/C125-128)，而L-N-Decyl-Idp明显有效.
AbstractWe have studied the antitumor effect of liposome-entrapped cis-bis-N-decyl-iminodiacetato-1,2-diaminocyclohexane-platinum(II)(L-N-decyl-IDP)in mouse models of experimental tumor metastases. the liposomal preparation was compared with the free drug in suspension (F-N-decyl-IDP). In the intraperitoneal (ip) L1210 leukemia model, a single ip injection at the maximum tolerated dose (MTD) of both the free drug and the liposomal drug was equally effective (%T/C 175). However, the free drug was more effective in a triple ip injection schedule at the MTD (%T/C 500 for F-N-decyl-IDP vs. 300 for L-N-decyl-IDP), with twoofsix animals cured by the free drug. In the intravenous (iv) L1210 leukemia model, a single iv injection at the MTD was ineffective for the free drug and only marginally effective for the liposomal preparation (%T/C 112 for F-N-decly-IDP vs. 125 for L-N-decyl-IDP). In a triple iv injection at the MTD, F-N-decyl-IDP was only marginally effective (%T/C 125-128), while L-N-decyl-IDP was clearly...
脂质体包埋的阿霉素抑制 M 5076 肿瘤的肝转移。
DOI：
10.1089/cdd.1983.1.43
发表时间：
1983
期刊：
Cancer drug delivery
影响因子：
--
作者：
Mayhew,E;Rustum,Y;Vail,WJ
通讯作者：
Vail,WJ
封装在多层囊泡中的顺-双-环戊烯羧基-1,2-二氨基环己烷铂(II)的毒性和抗肿瘤活性。
影响因子：
11.2
作者：
Perez-Soler,R;Khokhar,AR;Hacker,MP;Lopez-Berestein,G
通讯作者：
Lopez-Berestein,G
顺铂与新型水溶性抗肿瘤铂络合物：N-甲基-亚氨基二乙酸基-二氨基环己烷铂 (II) 在啮齿类动物中的肾脏和肠道毒性比较。
影响因子：
3.8
作者：
Newman,RA;Khokhar,AR;Sunderland,BA;Travis,EL;Bulger,RE
通讯作者：
Bulger,RE