Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.
Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.
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DOI：
10.1016/j.pharmthera.2016.09.005
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发表时间：
2017-03
影响因子：
13.5
通讯作者：
Henderson NC
中科院分区：
文献类型：
--
作者：
Murray IR;Baily JE;Chen WCW;Dar A;Gonzalez ZN;Jensen AR;Petrigliano FA;Deb A;Henderson NC
周细胞是存在于微脉管系统内的内皮周围间充质细胞。骨骼肌和心脏周细胞现在被认为在正常组织稳态中履行越来越多的功能，包括通过维持血管稳定性和调节毛细血管流动来促进微血管功能。在肌肉损伤的情况下，周细胞通过释放营养因子和调节局部免疫反应来促进再生微环境。在骨骼肌中，周细胞也通过分化成肌纤维直接促进组织愈合。相反，周细胞也与疾病状态的发展有关，包括纤维化、异位骨化和钙化、动脉粥样硬化和肿瘤血管生成。尽管越来越多的认识周细胞的异质性，它还不清楚是否特定的周细胞亚群负责骨骼肌和心肌稳态和疾病的个人功能。
Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognized to fulfill an increasing number of functions in normal tissue homeostasis, including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states, including fibrosis, heterotopic ossication and calcification, atherosclerosis, and tumor angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.
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影响因子：
23.9
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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