Quantification of Anterior Chamber Cells in Children With Uveitis Using Anterior Segment Optical Coherence Tomography.
Quantification of Anterior Chamber Cells in Children With Uveitis Using Anterior Segment Optical Coherence Tomography.
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DOI：
10.1016/j.ajo.2022.05.012
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发表时间：
2022-09
影响因子：
4.2
通讯作者：
Holland, Gary N.
中科院分区：
文献类型：
--
作者：
Tsui, Edmund;Chen, Judy L.;Jackson, Nicholas J.;Leyva, Omar;Rasheed, Haroon;Baghdasaryan, Elmira;Fung, Simon S. M.;Mccurdy, Deborah K.;Sadda, Srinivas R.;Holland, Gary N.
目的评价眼前节光学相干断层扫描（AS-OCT）测量葡萄膜炎儿童前房（AC）细胞的可行性，并比较不同AS-OCT采集模式。效度和信度分析。我们招募了年龄小于18岁的葡萄膜炎累及眼前节的儿童和无眼病的儿童作为对照。所有患者均接受AC细胞临床分级。使用Optovue Avanti RTVue XR AS-OCT获得每只眼睛的AC图像。使用两种采集模式：单一横截面线扫描和星号模式的8线径向扫描。两名独立的、设盲的分级员在AS-OCT图像上手动计数细胞。使用组内相关（ICC）评估评分者一致性。纳入了30名葡萄膜炎儿童（59只眼）（中位年龄13.0岁，范围3-17岁）和20名对照儿童（40只眼，中位年龄10.5岁，范围4-17岁）。每种临床细胞等级的眼睛数量如下：无，32（54%）; 0.5+，12（20.3%）; 1+，5（8.5%）; 2+，8（13.6%）; 3+，2（3.4%）。线扫描和放射扫描的ICC分别为0.87和0.90。对于合并分级器结果，采集模式之间没有显著差异（差异的95%置信区间[CI]：-0.04至0.14）。线扫描与放射状扫描细胞计数的ICC为0.85（95% CI：0.69-0.90）。对照眼在AS-OCT图像上没有细胞。采用AS-OCT对葡萄膜炎儿童AC细胞进行定量是可行的，并且在不同分级器和采集模式之间具有良好的可靠性。
To evaluate the feasibility of anterior segment optical coherence tomography (AS-OCT) for measuring anterior chamber (AC) cells in children with uveitis and to compare different AS-OCT acquisition modes. Validity and reliability analysis. We enrolled children younger than 18 years of age who had uveitis involving the anterior segment and children without eye disease as controls. All underwent clinical grading of AC cells. AC images of each eye were obtained using the Optovue Avanti RTVue XR AS-OCT. Two acquisition modes were used: a single cross-sectional line scan and an 8-line radial scan in an asterisk pattern. Two independent, masked graders counted cells manually on AS-OCT images. Rater agreement was assessed using intraclass correlation (ICC). Included were 30 children (59 eyes) with uveitis (median age 13.0 years, range 3–17 years) and 20 control children (40 eyes, median age 10.5 years, range 4–17 years). The number of eyes assigned each clinical grade of cells were as follows: none, 32 (54%); 0.5+, 12 (20.3%); 1+, 5 (8.5%); 2+, 8 (13.6%); 3+, 2 (3.4%). ICC of graders for line and radial scan protocols were 0.87 and 0.90. There was no significant difference between acquisition modes for pooled grader results (95% confidence interval [CI] for difference: −0.04 to 0.14). ICC of cell counts between line and radial scan protocols was 0.85 (95% CI: 0.69–0.90). No control eyes had cells on AS-OCT images. Quantification of AC cell in children with uveitis is feasible with AS-OCT and has excellent reliability between different graders and acquisition modes.
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影响因子：
13.3
作者：
Akbarali, Saira;Rahi, Jugnoo S.;Solebo, Ameenat L.
通讯作者：
Solebo, Ameenat L.
影响因子：
4.2
作者：
McCannel, CA;Holland, GN;Yang, MC
通讯作者：
Yang, MC
影响因子：
4.2
作者：
Davis, JL;Dacanay, LM;Feuer, WJ
通讯作者：
Feuer, WJ
DOI：
10.1007/s00417-016-3340-z
发表时间：
2016-09-01
影响因子：
2.7
作者：
Oray, Merih;Khachatryan, Naira;Foster, C. Stephen
通讯作者：
Foster, C. Stephen
影响因子：
4.7
作者：
Angeles-Han, Sheila T.;Ringold, Sarah;Reston, James
通讯作者：
Reston, James