Diffusion tensor imaging detects white matter abnormalities and associated cognitive deficits in chronic adolescent TBI.
Diffusion tensor imaging detects white matter abnormalities and associated cognitive deficits in chronic adolescent TBI.
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DOI：
10.3109/02699052.2012.750756
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发表时间：
2013
期刊：
影响因子：
1.9
通讯作者：
Wade SL
中科院分区：
文献类型：
--
作者：
Adamson C;Yuan W;Babcock L;Leach JL;Seal ML;Holland SK;Wade SL
这项研究利用扩散张量成像 (DTI) 检查了青春期 TBI 后白质微观结构的长期变化。据推测，患有 TBI 的青少年的白质完整性会受到损害，并且与执行功能和认知能力的测量相关。本研究采用全脑、体素方式对 12-17 岁青少年（平均年龄 = 15.06）TBI 与年龄和性别匹配队列（平均年龄 = 15.37）的 DTI 指数进行统计比较。这项研究对 17 名受伤后 1-3 年内患有复杂性轻度至重度 TBI 的青少年和 13 名健康青少年进行了扫描。 DTI 分析采用基于区域的空间统计 (TBSS)。 TBI 组的总体扩散率升高，右半球的轴向扩散率增加。在 TBI 组中，白质完整性与文字阅读、计划和处理时间相关，但与健康对照组无关。检测到的轴向扩散率异常可能反映了损伤后的神经元再生和大脑重组。这些发现提供了青春期创伤性脑损伤后脑白质持续改变的初步证据。 DTI 指数与 TBI 后认知表现的关联为白质完整性和 TBI 后表现之间的联系提供了初步支持。
This study examined long-term alterations in white matter microstructure following TBI in adolescence using diffusion tensor imaging (DTI). It was hypothesized that white matter integrity would be compromised in adolescents with TBI and would correlate with measures of executive functioning and cognitive abilities. This study employed whole-brain, voxel-wise, statistical comparison of DTI indices in youth of 12–17 years old (mean = 15.06) with TBI vs an age- and gender-matched cohort (mean age = 15.37). This study scanned 17 adolescents with complicated-mild-to-severe TBI, 1–3 years after injury, and 13 healthy adolescents. Tract-Based Spatial Statistics (TBSS) was employed for DTI analysis. Overall diffusivity elevations were found in the TBI group with increases in axial diffusivity in the right hemisphere. White matter integrity was associated with word reading, planning and processing times in the TBI group, but not healthy controls. The detected abnormalities in axial diffusivity may reflect neuronal regeneration and cerebral reorganization after injury. These findings provide tentative evidence of persistent white matter alteration following TBI in adolescence. Associations of DTI indices with cognitive performance following TBI provide tentative support for links between white matter integrity and performance post-TBI.
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