Targeting sirtuin-1 in Huntington's disease: rationale and current status.
Targeting sirtuin-1 in Huntington's disease: rationale and current status.
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DOI：
10.1007/s40263-013-0055-0
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发表时间：
2013-05
期刊：
影响因子：
6
通讯作者：
Duan, Wenzhen
中科院分区：
文献类型：
--
作者：
Duan, Wenzhen
Huntington’s disease (HD) is an autosomal dominant hereditary disease caused by a trinucleotide repeat mutation in the huntingtin gene that results in an increased number of glutamine residues in the N terminus of huntingtin protein. Mutant huntingtin leads to progressive impairment of motor function, cognitive dysfunction, and neuropsychiatric disturbance. There are no disease-modifying treatments available. During the past decade, Sirtuin-1 (SIRT1) has been the focus of intense investigation and discussion because it regulates longevity in multiple organisms and has shown beneficial effects in a variety of models of neurodegenerative disorders. Studies in different animal models provide convincing evidence that SIRT1 protects neurons in mouse models of HD well as in Caenorhabditis. elegans, although controversial results were reported in a fly model. Indeed, many connections exist between the deacetylation function of SIRT1 and its role in neuroprotection. As a result, pharmacological interventions targeting SIRT1 might become promising strategies to combat HD. This review summarizes recent progress in SIRT1 research, with a focus on the specificity of this protein as a potential therapeutic target for HD, as well as existing challenges for developing SIRT1 modulators for clinical use.
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影响因子：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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Gems, David
DOI：
10.1146/annurev.pathol.4.110807.092250
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
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Haigis MC;Sinclair DA
通讯作者：
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Chopra V;Quinti L;Kim J;Vollor L;Narayanan KL;Edgerly C;Cipicchio PM;Lauver MA;Choi SH;Silverman RB;Ferrante RJ;Hersch S;Kazantsev AG
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