Inferring functional connections between neurons.
Inferring functional connections between neurons.
复制标题
推断神经元之间的功能连接。
DOI:
10.1016/j.conb.2008.11.005
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发表时间:
2008-12
影响因子:
5.7
通讯作者:
Koerding, Konrad P.
中科院分区:
文献类型:
--
作者:
Stevenson, Ian H.;Rebesco, James M.;Miller, Lee E.;Koerding, Konrad P.
A central question in neuroscience is how interactions between neurons give rise to behavior. In many electrophysiological experiments, the activity of a set of neurons is recorded while sensory stimuli or movement tasks are varied. Tools that aim to reveal underlying interactions between neurons from such data can be extremely useful. Traditionally, neuroscientists have studied these interactions using purely descriptive statistics (cross-correlograms or joint peri-stimulus time histograms). However, the interpretation of such data is often difficult, particularly as the number of recorded neurons grows. Recent research suggests that model-based, maximum likelihood methods can improve these analyses. In addition to estimating neural interactions, application of these techniques has improved decoding of external variables, created novel interpretations of existing electrophysiological data, and may provide new insight into how the brain represents information.
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