Quantification of volatile metabolites derived from garlic in human breast milk.

Quantification of volatile metabolites derived from garlic in human breast milk.
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人母乳中大蒜挥发性代谢物的定量

DOI:
10.1016/j.foodchem.2018.09.039
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发表时间:
2019
期刊:
影响因子:
8.8
通讯作者:
A. Buettner
A. Buettner
中科院分区:
农林科学1区
文献类型:
--
作者:
L. Scheffler;C. Sharapa;A. Buettner

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据报道,母亲在怀孕期间和母乳喂养期间的大蒜摄入量与婴儿后来接受大蒜的可能性有关。然而,大蒜成分在人体内的代谢及其消除和排泄到人乳中的可能性尚不完全清楚。在之前的研究中,我们在人乳和人尿中发现了挥发性大蒜衍生代谢物,即烯丙基甲基硫醚、烯丙基甲基亚砜和烯丙基甲基砜。为了在更大的队列中监测这些大蒜代谢物的排泄,我们在总共18组母乳中对这些代谢物进行了量化,其中每组母乳由食用大蒜前收集的一个样本和食用大蒜后收集的三个样本组成。分析表明,在食用大蒜后1-3.5 h,代谢物浓度最为丰富,在代谢物浓度和时间排泄方面,被试者之间存在明显差异。
Maternal garlic intake during pregnancy and the breastfeeding period has been reported to be associated with the potential of modulating later garlic acceptance in infants. However, the metabolism of garlic constituents in humans and their elimination and potential excretion into human milk are not yet fully understood. In previous studies, we identified volatile garlic-derived metabolites in human milk as well as in human urine, namely allyl methyl sulfide, allyl methyl sulfoxide and allyl methyl sulfone. To monitor the excretion of these garlic metabolites in a larger cohort, we quantified these metabolites in a total of 18 human milk sets, whereby each set comprised of one sample collected before and three samples after garlic consumption. The analyses revealed that the concentrations of the metabolites were most abundant 1–3.5 h after garlic consumption, with distinct differences between test persons regarding metabolite concentrations as well as temporal excretion.
口服含有 1,8-桉树脑的药物制剂后,母乳中的香气随时间发生变化。
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