Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy
Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy
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β 受体阻滞剂可防止特发性扩张型心肌病患者血浆 ACE2 活性与超声心动图参数的相关性
DOI：
10.1097/fjc.0000000000000156
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发表时间：
2015
影响因子：
3
通讯作者：
Walther
中科院分区：
文献类型：
--
作者：
Wang Y;Moreira Mda C;Heringer-Walther S;Schultheiss H.P;Siems W;Wessel N;Walther
血浆血管紧张素转换酶（ACE）2活性已被证明是一个独立的预后指标在恰加斯病，同样有效的B型利钠肽。本研究的目的是探讨特发性扩张型心肌病（DCM）患者循环ACE 2活性的预后潜力。从患有特发性DCM的患者和健康对照受试者中抽取血液样品。根据纽约心脏协会分级将DCM患者分为2组。用荧光法测定血浆ACE 2活性。DCM患者血浆ACE 2活性显著升高，与临床严重程度相关。扩张型心肌病患者的心功能与超声心动图参数相关。此外，血浆ACE 2活性具有预测心脏死亡和心脏移植的潜力。然而，与Chagas病患者相比，DCM患者中ACE 2活性的相关性和预测价值要小得多。DCM患者的β受体阻滞剂治疗被确定为防止循环ACE2活性与超声心动图参数之间的关联。尽管在无β受体阻滞剂的DCM患者的血液样品中ACE2活性在与疾病的严重程度相关以及预测死亡和心脏移植方面是有效的，但其相关性和预测效力被β受体阻滞剂治疗显著降低。
Plasma angiotensin-converting enzyme (ACE) 2 activity has been demonstrated to be an independent prognostic marker in Chagas' disease, equally potent as B-type natriuretic peptide. This study aimed to investigate the prognostic potency of circulating ACE2 activity in patients with idiopathic dilated cardiomyopathy (DCM). Blood samples were withdrawn from patients with idiopathic DCM and healthy control subjects. The DCM patients were subdivided into 2 groups according to their New York Heart Association classification. The plasma ACE2 activity was measured by a fluorescence method. Plasma ACE2 activity was significantly increased in DCM patients, correlating with clinical severity. It was correlating with echocardiographic parameters in patients with DCM. Furthermore, plasma ACE2 activity had the potency to predict cardiac death and heart transplantation. However, compared with patients with Chagas' disease, the correlation and predictive value of ACE2 activity in patients with DCM was much less pronounced. Beta blocker treatment in patients with DCM was identified to prevent the association between circulating ACE2 activity and echocardiographic parameters. Although ACE2 activity in blood samples of patients with DCM without beta blockers is potent in correlating with the severity of disease and in predicting death and heart transplantation, its correlation and prediction potency are significantly diminished by beta blocker treatment.
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影响因子：
39.3
作者：
Swedberg, K;Olsson, LG;Poole-Wilson, P
通讯作者：
Poole-Wilson, P
DOI：
10.1073/pnas.1432869100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Santos, RAS;Silva, ACSE;Walther, T
通讯作者：
Walther, T
影响因子：
1.9
作者：
Moreira, Maria da Consolacao V.;Heringer-Walther, Silvia;Walther, Thomas
通讯作者：
Walther, Thomas
影响因子：
3
作者：
Heringer-Walther, Silvia;Moreira, Maria da Consolacao V.;Walther, Thomas
通讯作者：
Walther, Thomas
β阻滞剂（卡维地洛或美托洛尔）对慢性心力衰竭中肾素-血管紧张素-醛固酮系统和利尿钠肽激活的影响。
影响因子：
2.8
作者：
J. Fung;Cheuk;G. Yip;Skiva Chan;T. Yandle;A. Richards;M. Nicholls;J. Sanderson
通讯作者：
J. Sanderson