Evaluation of a rapid antigen test (Panbio™ COVID-19 Ag rapid test device) for SARS-CoV-2 detection in asymptomatic close contacts of COVID-19 patients.
Evaluation of a rapid antigen test (Panbio™ COVID-19 Ag rapid test device) for SARS-CoV-2 detection in asymptomatic close contacts of COVID-19 patients.
复制标题
DOI：
10.1016/j.cmi.2020.12.022
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Navarro D
中科院分区：
文献类型：
--
作者：
Torres I;Poujois S;Albert E;Colomina J;Navarro D
关于快速抗原检测（RAD）检测识别SARS-CoV-2感染的无症状个体的性能信息有限。在本田间研究中，我们为此目的评估了Panbio™ COVID-19 Ag快速检测装置（Abbott Diagnostics，Jena，德国）。共招募了634名个体（355名女性;中位年龄37岁;范围9-87岁）。从COVID-19病例的家庭（n = 338）和非家庭接触者（n = 296）中采集了两份鼻咽拭子。在护理点进行RAD测试。使用的RT-PCR测试是TaqPath COVID-19 Combo Kit（Thermo Fisher Scientific，MA，USA）。家庭接触者在指示病例诊断后中位数2天（范围1-7）进行检测，而非家庭接触者（n = 296）在接触后中位数6天（范围1-7）进行检测。总共有79人（12.4%）通过RT-PCR检测呈阳性，其中38人（48.1%）产生阳性RAD结果。RAD试验的总体灵敏度和特异性分别为48.1%（95% CI 37.4-58.9）和100%（95% CI 99.3-100）。家庭接触者的敏感性（50.8%; 95% CI 38.9-62.5）高于非家庭接触者（35.7%; 95% CI 16.3-61.2%）。RAD测试阳性的个体比阴性的个体更有可能（p < 0.001）出现症状。Panbio检测在COVID-19患者的无症状密切接触者中显示出较低的敏感性，特别是在非家庭接触者中。尽管如此，在这一组中建立上呼吸道采集的最佳时间似乎是确定检测灵敏度的必要条件。
There is limited information on the performance of rapid antigen detection (RAD) tests to identify SARS-CoV-2-infected asymptomatic individuals. In this field study, we evaluated the Panbio™ COVID-19 Ag Rapid Test Device (Abbott Diagnostics, Jena, Germany) for this purpose. A total of 634 individuals (355 female; median age, 37 years; range, 9–87) were enrolled. Two nasopharyngeal swabs were collected from household (n = 338) and non-household contacts (n = 296) of COVID-19 cases. RAD testing was carried out at the point of care. The RT-PCR test used was the TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific, MA, USA). Household contacts were tested at a median of 2 days (range, 1–7) after diagnosis of the index case, whereas non-household contacts (n = 296) were tested at a median of 6 days (range, 1–7) after exposure. In total, 79 individuals (12.4%) tested positive by RT-PCR, of whom 38 (48.1%) yielded positive RAD results. The overall sensitivity and specificity of the RAD test was 48.1% (95% CI 37.4–58.9) and 100% (95% CI 99.3–100), respectively. Sensitivity was higher in household (50.8%; 95% CI 38.9–62.5) than in non-household (35.7%; 95% CI 16.3–61.2%) contacts. Individuals testing positive by RAD test were more likely (p < 0.001) to become symptomatic than their negative counterparts. The Panbio test displays low sensitivity in asymptomatic close contacts of COVID-19 patients, particularly in non-household contacts. Nonetheless, establishing the optimal timing for upper respiratory tract collection in this group seems imperative to pinpoint test sensitivity.
登录
查看更多内容
DOI：
10.1016/j.cmi.2020.11.004
发表时间：
2021-03
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Albert E;Torres I;Bueno F;Huntley D;Molla E;Fernández-Fuentes MÁ;Martínez M;Poujois S;Forqué L;Valdivia A;Solano de la Asunción C;Ferrer J;Colomina J;Navarro D
通讯作者：
Navarro D
DOI：
10.1016/j.jcv.2020.104659
发表时间：
2020-12
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Linares M;Pérez-Tanoira R;Carrero A;Romanyk J;Pérez-García F;Gómez-Herruz P;Arroyo T;Cuadros J
通讯作者：
Cuadros J
影响因子：
64.8
作者：
Woelfel, Roman;Corman, Victor M.;Wendtner, Clemens
通讯作者：
Wendtner, Clemens
影响因子：
11.8
作者：
Nguyen Van Vinh Chau;Vo Thanh Lam;Le Van Tan
通讯作者：
Le Van Tan
影响因子：
11.8
作者：
Baggio, Stephanie;L'Huillier, Arnaud G.;Eckerle, Isabella
通讯作者：
Eckerle, Isabella