Meta-analysis Comparing Fluorescence Imaging with Radioisotope and Blue Dye-Guided Sentinel Node Identification for Breast Cancer Surgery.
Meta-analysis Comparing Fluorescence Imaging with Radioisotope and Blue Dye-Guided Sentinel Node Identification for Breast Cancer Surgery.
复制标题
DOI：
10.1245/s10434-020-09288-7
复制
发表时间：
2021-07
影响因子：
3.7
通讯作者：
Leff DR
中科院分区：
文献类型：
--
作者：
Kedrzycki MS;Leiloglou M;Ashrafian H;Jiwa N;Thiruchelvam PTR;Elson DS;Leff DR
腋窝前哨淋巴结活检（SLNB）的传统方法充满了并发症，如过敏反应，皮肤纹身，辐射和基础设施的限制。一种新的技术已经开发利用荧光成像淋巴映射。本荟萃分析旨在比较金标准蓝色染料和放射性同位素（BD-RI）技术与使用吲哚菁绿色（ICG）的荧光引导SLNB。本研究已在PROSPERO注册（CRD 42019129224）。使用医学主题标题（MESH）术语"手术"和"淋巴结"和"近红外荧光"和"吲哚菁绿"检索MEDLINE、EMBASE、Scopus和Web of Science数据库。纳入了包含乳腺癌手术中前哨淋巴结识别率原始数据的研究。异质性检验（使用Cochran's Q）确定使用固定或随机效应模型计算合并优势比（OR）。总体而言，筛选了1748项研究，其中10项符合荟萃分析的纳入标准。在前哨淋巴结识别方面，ICG与放射性同位素（RI）相当（OR 2.58，95%置信区间[CI] 0.35 - 19.08，p <0.05），但优于蓝色染料（BD）（OR 9.07，95% CI 6.73 - 12.23，p <0.05）。此外，ICG优于金标准BD-RI技术（OR 4.22，95%CI 2.17 - 8.20，p <0.001），为上级。ICG荧光成像鉴别腋窝前哨淋巴结与RI单技术鉴别腋窝前哨淋巴结相当，但优于RI-BD双技术和BD单技术，且具有上级优势。使用RI和/或BD的医院可以考虑将其实践改为ICG，因为其疗效相当，安全性得到改善，而且对医院基础设施的负担较轻。本文的在线版本（10.1245/s10434 - 020 - 09288 - 7）包含补充材料，可供授权用户使用。
Conventional methods for axillary sentinel lymph node biopsy (SLNB) are fraught with complications such as allergic reactions, skin tattooing, radiation, and limitations on infrastructure. A novel technique has been developed for lymphatic mapping utilizing fluorescence imaging. This meta-analysis aims to compare the gold standard blue dye and radioisotope (BD-RI) technique with fluorescence-guided SLNB using indocyanine green (ICG). This study was registered with PROSPERO (CRD42019129224). The MEDLINE, EMBASE, Scopus, and Web of Science databases were searched using the Medical Subject Heading (MESH) terms ‘Surgery’ AND ‘Lymph node’ AND ‘Near infrared fluorescence’ AND ‘Indocyanine green’. Studies containing raw data on the sentinel node identification rate in breast cancer surgery were included. A heterogeneity test (using Cochran’s Q) determined the use of fixed- or random-effects models for pooled odds ratios (OR). Overall, 1748 studies were screened, of which 10 met the inclusion criteria for meta-analysis. ICG was equivalent to radioisotope (RI) at sentinel node identification (OR 2.58, 95% confidence interval [CI] 0.35–19.08, p < 0.05) but superior to blue dye (BD) (OR 9.07, 95% CI 6.73–12.23, p < 0.05). Furthermore, ICG was superior to the gold standard BD-RI technique (OR 4.22, 95% CI 2.17–8.20, p < 0.001). Fluorescence imaging for axillary sentinel node identification with ICG is equivalent to the single technique using RI, and superior to the dual technique (RI-BD) and single technique with BD. Hospitals using RI and/or BD could consider changing their practice to ICG given the comparable efficacy and improved safety profile, as well as the lesser burden on hospital infrastructure. The online version of this article (10.1245/s10434-020-09288-7) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
3.7
作者：
Chi C;Ye J;Ding H;He D;Huang W;Zhang GJ;Tian J
通讯作者：
Tian J
影响因子：
3.9
作者：
Demarchi, Marco Stefano;Karenovics, Wolfram;Triponez, Frederic
通讯作者：
Triponez, Frederic
DOI：
10.1016/s1470-2045(14)70460-7
发表时间：
2014-11
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Donker M;van Tienhoven G;Straver ME;Meijnen P;van de Velde CJ;Mansel RE;Cataliotti L;Westenberg AH;Klinkenbijl JH;Orzalesi L;Bouma WH;van der Mijle HC;Nieuwenhuijzen GA;Veltkamp SC;Slaets L;Duez NJ;de Graaf PW;van Dalen T;Marinelli A;Rijna H;Snoj M;Bundred NJ;Merkus JW;Belkacemi Y;Petignat P;Schinagl DA;Coens C;Messina CG;Bogaerts J;Rutgers EJ
通讯作者：
Rutgers EJ
影响因子：
2.7
作者：
Grischke, E. -M.;Roehm, C.;Wallwiener, D.
通讯作者：
Wallwiener, D.
影响因子：
45.3
作者：
Giuliano, AE;Haigh, PI;Turner, RR
通讯作者：
Turner, RR