IGF-I expression in blood vessels varies with vascular load.
IGF-I expression in blood vessels varies with vascular load.
复制标题
血管中IGF-I的表达随血管负荷的变化而变化。
DOI：
10.1111/j.1748-1716.1987.tb08055.x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
A. Skottner
中科院分区：
文献类型：
--
作者：
H. Hansson;E. Jennische;A. Skottner
本研究旨在探讨胰岛素样生长因子I（IGF-I，生长调节素C）在血管中的免疫反应性是否与成年大鼠的血管负荷有关。右股动脉闭塞导致24小时内对侧左股动脉中IGF-I免疫反应性强烈增加，闭塞远端右股动脉中IGF-I表达显著降低。平滑肌细胞标记的增加持续至少21天。不活动的右后肢，继发于缺血性损伤，同样诱导IGF-I免疫反应性显着增加，在24小时内，在股血管的未受损，对侧左后肢。结论：IGF-I免疫反应性随血管壁动态负荷的变化而变化。IGF-I可能作为一种副激素，通过旁分泌和/或自分泌机制发挥作用，参与调节血管对应激的结构适应。
The present study was designed to investigate if the immunoreactivity of insulin-like growth factor I (IGF-I, somatomedin C) in blood vessels was changed in relation to the vascular load in adult rats. Occlusion of the right femoral artery resulted within 24 h in a strongly increased IGF-I immunoreactivity in the media of the contralateral, left, femoral artery and a significant decrease in the IGF-I expression in the right femoral artery distal to the occlusion. The increased labelling of the smooth muscle cells persisted for at least 21 days. Inactivity of the right hind limb, secondarily to an ischaemic insult, likewise induced a significant increase in IGF-I immunoreactivity, within 24 h, in the femoral vessels of the undamaged, contralateral left hind limb. It is concluded that IGF-I immunoreactivity varies with the dynamic load in the vascular walls. It is proposed that IGF-I may serve as a parahormone exerting its effect by paracrine and/or autocrine mechanisms, taking part in regulating the structural adaption of blood vessels in response to stress.
DOI：
10.1073/pnas.81.3.935
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DERCOLE, AJ;STILES, AD;UNDERWOOD, LE
通讯作者：
UNDERWOOD, LE