Obesity is associated with impaired immune response to influenza vaccination in humans.
Obesity is associated with impaired immune response to influenza vaccination in humans.
复制标题
肥胖与人类流感疫苗接种的免疫反应受损有关。
DOI：
10.1038/ijo.2011.208
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发表时间：
2012-08
影响因子：
4.9
通讯作者：
Beck, M. A.
中科院分区：
文献类型：
--
作者：
Sheridan, P. A.;Paich, H. A.;Handy, J.;Karlsson, E. A.;Hudgens, M. G.;Sammon, A. B.;Holland, L. A.;Weir, S.;Noah, T. L.;Beck, M. A.
肥胖是H1N1大流行性流感发病和死亡的独立危险因素。流感是一项重大的公共卫生威胁，每年在全世界造成约25万至50万人死亡。世界上超过十分之一的成年人肥胖，超过三分之二的美国成年人超重或肥胖。尽管流感疫苗对公共卫生具有明显的重要性，但没有研究比较过健康体重、超重和肥胖人群对流感疫苗的体液或细胞免疫反应。该研究采用方便样本来确定健康体重、超重和肥胖参与者在接种疫苗后1个月和12个月对2009-2010年灭活三价流感疫苗（TIV）的抗体反应。此外，在流感刺激的外周血单核细胞（PBMC）培养中，检测了CD8+ T细胞的活化以及干扰素-γ和颗粒酶B的表达。身体质量指数（BMI）与TIV酶联免疫吸附试验检测到的IgG抗体初始倍数增加呈正相关，在一项亚组研究中得到HAI抗体的证实。然而，接种疫苗12个月后，较高的BMI与流感抗体滴度的较大下降有关。研究表明，与体重正常的个体相比，肥胖个体的CD8+ t细胞活性降低，功能蛋白表达减少。这些结果表明，肥胖可能会损害人体对流感病毒产生保护性免疫反应的能力。
Obesity is an independent risk factor for morbidity and mortality from pandemic influenza H1N1. Influenza is a significant public health threat, killing an estimated 250 000–500 000 people worldwide each year. More than one in ten of the world's adult population is obese and more than two-thirds of the US adult population is overweight or obese. No studies have compared humoral or cellular immune responses to influenza vaccination in healthy weight, overweight and obese populations despite clear public health importance. The study employed a convenience sample to determine the antibody response to the 2009–2010 inactivated trivalent influenza vaccine (TIV) in healthy weight, overweight and obese participants at 1 and 12 months post vaccination. In addition, activation of CD8+ T cells and expression of interferon-γ and granzyme B were measured in influenza-stimulated peripheral blood mononuclear cell (PBMC) cultures. Body mass index (BMI) correlated positively with higher initial fold increase in IgG antibodies detected by enzyme-linked immunosorbent assay to TIV, confirmed by HAI antibody in a subset study. However, 12 months post vaccination, higher BMI was associated with a greater decline in influenza antibody titers. PBMCs challenged ex vivo with vaccine strain virus, demonstrated that obese individuals had decreased CD8+ T-cell activation and decreased expression of functional proteins compared with healthy weight individuals. These results suggest obesity may impair the ability to mount a protective immune response to influenza virus.
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