Leukemia Stem Cells in the Pathogenesis, Progression, and Treatment of Acute Myeloid Leukemia.
Leukemia Stem Cells in the Pathogenesis, Progression, and Treatment of Acute Myeloid Leukemia.
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DOI：
10.1007/978-981-13-7342-8_5
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发表时间：
2019
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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尽管在了解白血病干细胞(LSCs)的生物学方面已经取得了重大进展，但关于LSCs概念的一些关键问题还没有在实验上得到令人满意的解决。因此，由于在有效识别LSCs方面的技术限制引起的争议，LSCs的临床相关性仍然不是很清楚。这阻碍了我们完全解决前LSCs和LSCs的遗传异质性和代谢/表观遗传可塑性的特征。随着人源化免疫缺陷小鼠的发展和使用，我们能够更准确地分析LSCs的功能及其与骨髓利基的相互作用。此外，最近在LSCs中发现了一些有希望的靶点，包括在AML细胞中高表达的Sonic Hedgehog(SHH)和bcl2。人们希望，新的抗LSC化合物将在临床试验中得到充分测试，以确定其治疗人类白血病的有效性。
Despite the significant progress that has been made in understanding the biology of leukemia stem cells (LSCs), some key questions regarding the concept of LSCs have not as yet been satisfactorily addressed experimentally. As a result, the clinical relevance of LSCs remains less than clear due to controversies caused largely by technical limitations in efficiently identifying LSCs. This has impeded our ability to fully address the features of genetic heterogeneity and metabolic/epigenetic plasticity of pre-LSCs and LSCs. With the development and use of humanized immunocompromised mice, we are able to more precisely analyze LSCs for their functions and interaction with the bone marrow niche. In addition, some promising targets in LSCs have recently been identified, including Sonic Hedgehog (SHH) and BCL-2, which are highly expressed in AML cells. It is hopeful that new anti-LSC compounds will be tested fully in clinical trials for their efficacy in treating human leukemias.
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影响因子：
20.3
作者：
Anderson, Mary Ann;Deng, Jing;Roberts, Andrew W.
通讯作者：
Roberts, Andrew W.
在健康个体中预测急性髓样白血病的风险。
影响因子：
64.8
作者：
Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
通讯作者：
Shlush LI
影响因子：
50.3
作者：
Abdel-Wahab O;Adli M;LaFave LM;Gao J;Hricik T;Shih AH;Pandey S;Patel JP;Chung YR;Koche R;Perna F;Zhao X;Taylor JE;Park CY;Carroll M;Melnick A;Nimer SD;Jaffe JD;Aifantis I;Bernstein BE;Levine RL
通讯作者：
Levine RL
DOI：
10.1073/pnas.1422749112
发表时间：
2015-08-25
影响因子：
11.1
作者：
Agerstam, Helena;Karlsson, Christine;Fioretos, Thoas
通讯作者：
Fioretos, Thoas
影响因子：
15.9
作者：
Bellodi, Cristian;Lidonnici, Maria Rosa;Calabretta, Bruno
通讯作者：
Calabretta, Bruno