Influence of Sex and ERK MAPK on the Pressure Reactivity Index in Newborn Piglets After Fluid Percussion Injury.
Influence of Sex and ERK MAPK on the Pressure Reactivity Index in Newborn Piglets After Fluid Percussion Injury.
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DOI：
10.1007/s12975-012-0196-3
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发表时间：
2012-12
影响因子：
6.9
通讯作者：
Armstead, William M.
中科院分区：
文献类型：
--
作者：
Kosty, Jennifer;Riley, John;Liang, Jiaming;Armstead, William M.
液体冲击损伤（FPI）后，雄性仔猪比雌性仔猪的自动调节损伤更大。这部分是由细胞外信号相关激酶丝裂原激活蛋白激酶 (ERK MAPK) 的更大上调介导的。我们假设这些趋势将通过压力反应指数（PRx）（一种自动调节的临床指标）来反映。我们进一步假设 PRx 值与软脑膜动脉对低血压的扩张反应密切相关。对雄性和雌性仔猪进行 FPI 处理，并在损伤后 30 分钟用媒介物或 ERK MAPK 拮抗剂 U 0126 (1 mg/kg IV) 进行治疗。 FPI 导致未经治疗的两性仔猪中 CSF ERK MAPK 上调，但雄性仔猪的 PRx 值显着高于雌性仔猪。施用 U 0126 后，两性的 ERK MAPK 水平升高均被阻断，而男性的 PRx 值显着改善。 PRx 和软脑膜动脉血管舒缩活动之间存在很强的相关性。这些数据支持之前的观察结果，即雄性仔猪在 FPI 后表现出 ERK MAPK 介导的可逆性自动调节损伤，这由 PRx 反映出来。 PRx 与软脑膜动脉血管舒缩活动之间的强相关性支持使用该指数持续监测患者脑血管自动调节的实践。
Greater impairment in autoregulation is seen in male versus female piglets following fluid percussion injury (FPI). This is partially mediated by a greater upregulation of extracellular signal-related kinase mitogen-activated protein kinase (ERK MAPK). We hypothesized that these trends would be reflected by the pressure reactivity index (PRx), a clinical measure of autoregulation. We further hypothesized that PRx values would correlate well with pial artery dilatory responses to hypotension. Male and female piglets were subjected to FPI and treated with a vehicle or ERK MAPK antagonist U 0126 (1 mg/kg IV) 30 min post-injury. FPI led to upregulation of CSF ERK MAPK in untreated piglets of both sexes, however significantly higher PRx values were seen in male versus female piglets. Following administration of U 0126, elevation of ERK MAPK levels was blocked in both sexes and PRx values were significantly improved in the male. A strong correlation was seen between the PRx and pial artery vasomotor activity. These data support previous observations that male piglets demonstrate reversible ERK MAPK-mediated impairment in autoregulation following FPI, which is reflected by the PRx. The strong correlation between the PRx and pial artery vasomotor activity supports the practice of continuously monitoring cerebrovascular autoregulation in patients using this index.
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影响因子：
8.3
作者：
Armstead, WM
通讯作者：
Armstead, WM
DOI：
10.1098/rspb.1967.0002
发表时间：
1967-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DICKERSON, JW;DOBBING, J
通讯作者：
DOBBING, J
DOI：
10.1097/00005373-199705001-00002
发表时间：
1997-05-01
影响因子：
--
作者：
Chesnut, RM
通讯作者：
Chesnut, RM
影响因子：
8.3
作者：
Kasemsri, T;Armstead, WM
通讯作者：
Armstead, WM
影响因子：
8.8
作者：
Armstead WM;Kiessling JW;Kofke WA;Vavilala MS
通讯作者：
Vavilala MS