Skin microbiome alters attractiveness to Anopheles mosquitoes.
Skin microbiome alters attractiveness to Anopheles mosquitoes.
复制标题
皮肤微生物改变了对按蚊的吸引力。
DOI：
10.1186/s12866-022-02502-4
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发表时间：
2022-04-11
期刊：
影响因子：
4.2
通讯作者：
中科院分区：
文献类型：
--
作者：
有些人会产生特定的体味，这使他们比其他人对蚊子更有吸引力，因此感染媒介传播疾病的风险更高。皮肤微生物组可以将皮肤上的碳水化合物、脂肪酸和肽分解成蚊子可以分解的挥发物。在这里，我们研究了女性皮肤微生物组组成与对按蚊的吸引力水平之间的差异，以确定体味中的挥发物和与对蚊子吸引力较差的个体相关的代谢途径。我们使用行为分析来衡量参与者对 An 的吸引力。 coluzzii 蚊子，对皮肤采样的细菌进行 16S rRNA 扩增子测序，并对体味中的挥发物进行气相色谱分析。我们发现低吸引力组和高吸引力组之间的皮肤微生物组组成存在差异，特别是属于变形菌门、放线菌门和厚壁菌门的八种扩增子序列变体（ASV）。与低吸引力组相比，高吸引力组中的葡萄球菌 2 ASV 丰度是其四倍。人们发现这些 ASV 和已知对按蚊具有吸引力的挥发物之间存在关联。与那些被发现具有高度吸引力的参与者相比，丙酸途径在吸引力较差的参与者中更加丰富。我们的研究结果表明，人们对蚊子的吸引力的变化与皮肤微生物群的组成、可以改进气味诱饵陷阱或其他下一代病媒控制工具的知识有关。在线版本包含可在 10.1186/s12866-022-02502-4 获取的补充材料。
Some people produce specific body odours that make them more attractive than others to mosquitoes, and consequently are at higher risk of contracting vector-borne diseases. The skin microbiome can break down carbohydrates, fatty acids and peptides on the skin into volatiles that mosquitoes can differentiate. Here, we examined how skin microbiome composition of women differs in relation to level of attractiveness to Anopheles coluzzii mosquitoes, to identify volatiles in body odour and metabolic pathways associated with individuals that tend to be poorly-attractive to mosquitoes. We used behavioural assays to measure attractiveness of participants to An. coluzzii mosquitoes, 16S rRNA amplicon sequencing of the bacteria sampled from the skin and gas chromatography of volatiles in body odour. We found differences in skin microbiome composition between the poorly- and highly-attractive groups, particularly eight Amplicon Sequence Variants (ASVs) belonging to the Proteobacteria, Actinobacteria and Firmicutes phyla. Staphylococcus 2 ASVs are four times as abundant in the highly-attractive compared to poorly-attractive group. Associations were found between these ASVs and volatiles known to be attractive to Anopheles mosquitoes. Propanoic pathways are enriched in the poorly-attractive participants compared to those found to be highly-attractive. Our findings suggest that variation in attractiveness of people to mosquitoes is related to the composition of the skin microbiota, knowledge that could improve odour-baited traps or other next generation vector control tools. The online version contains supplementary material available at 10.1186/s12866-022-02502-4.
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DOI：
10.1098/rstb.2019.0811
发表时间：
2021-02-15
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Martinez J;Showering A;Oke C;Jones RT;Logan JG
通讯作者：
Logan JG
影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
DOI：
10.1016/0035-9203(95)90406-9
发表时间：
1995-11-01
影响因子：
2.2
作者：
Knols, BGJ;deJong, R;Takken, W
通讯作者：
Takken, W
影响因子：
1.9
作者：
Costantini, C;Birkett, MA;Pickett, JA
通讯作者：
Pickett, JA
影响因子：
15.5
作者：
Davis, Nicole M;Proctor, Diana M;Callahan, Benjamin J
通讯作者：
Callahan, Benjamin J