Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma.
Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma.
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DOI：
10.1186/1746-1596-8-47
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发表时间：
2013-03-25
影响因子：
2.6
通讯作者：
Zhao G
中科院分区：
文献类型：
--
作者：
Li M;Tang Y;Zang W;Xuan X;Wang N;Ma Y;Wang Y;Dong Z;Zhao G
探讨HAX-1 mRNA和蛋白在食管鳞状细胞癌（ESCC）中的表达及其与预后的关系。应用实时荧光定量RT-PCR和免疫组化方法检测112例食管鳞癌和112例相应非肿瘤组织中HAX-1 mRNA和蛋白的表达。根据随访数据绘制生存曲线。分析其预后与临床及病理特征的关系。食管鳞癌组织中HAX-1 mRNA的表达水平和HAX-1蛋白的强阳性率均显著高于正常对照组与非肿瘤性标本比较，差异有显著性（0.527 ± 0.060和45.54（0.121 ± 0.017和0.00%），在有淋巴结转移的ESCC样本中，淋巴结转移组食管鳞癌组织中癌旁淋巴结转移率分别为0.554 ± 0.054和71.11%，明显高于无淋巴结转移组（0.509 ± 0.058和28.36%）（P均< 0.01）。HAX-1 mRNA表达水平是食管鳞癌淋巴结转移的危险因素（P = 0.000）。淋巴结转移组与无转移组的生存曲线有显著性差异HAX-1蛋白表达+、++、+组间差异有统计学意义（P = 0.000）。（，P = 0.000）;但男性与女性患者之间无统计学意义≥60岁组与<60岁组比较，差异有统计学意义（P = 0.119）。HAX-1 mRNA（P = 0.000）和蛋白（P = 0.005）水平是影响胃癌生存的危险因素，而淋巴结转移（P = 0.477）与胃癌生存无关。食管鳞癌组织中存在HAX-1的高表达，HAX-1 mRNA水平是食管鳞癌淋巴结转移的危险因素。HAX-1 mRNA和蛋白水平是食管鳞癌患者生存的危险因素。HAX-1可能成为食管鳞癌治疗的新靶点。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/5130393079296037
To explore the expression of HAX-1 mRNA and protein in esophageal squamous cell carcinoma (ESCC) and its relation with the prognosis of patients with ESCC. The expression of HAX-1 mRNA and protein were detected with quantitative real-time RT-PCR and immunohistochemical method in 112 ESCC samples and 112 corresponding non-neoplastic samples. Survival curves were made with follow-up data. The relations of the prognosis with clinical and pathological characteristics were analyzed. The expression level of HAX-1 mRNA and the strong positive rate of HAX-1 protein were significantly higher in ESCC samples (0.527 ± 0.060 and 45.54%) than that in non-neoplastic samples (0.121 ± 0.017 and 0.00%), and in ESCC samples with lymph node metastasis (0.554 ± 0.054 and 71.11%) than that in ESCC samples without lymph node metastasis (0.509 ± 0.058 and 28.36%) (all P < 0.01). HAX-1 mRNA expression level was a risk factor of lymph node metastasis in patients with ESCC (P = 0.000). There were significant differences in survival curves between lymph node metastatic group and non-metastatic group (P = 0.000), and among groups of HAX-1 protein expression +, ++and +++(,P = 0.000); but no statistical significance between male patients and female patients (P = 0.119), and between ≥60 years old patients and <60 years old patients (P = 0.705). The level of HAX-1 mRNA (P = 0.000) and protein (P = 0.005) were risk factors of survival, but lymph node metastasis (P = 0.477) was not. There is HAX-1 over-expression in ESCC tissue and HAX-1 mRNA level is a risk factor of lymph node metastasis. The level of HAX-1 mRNA and protein were risk factors of survival in patients with ESCC. HAX-1 may be a novel therapeutic target for ESCC treatment. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5130393079296037
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肿瘤中 HAX-1 过度表达、剪接和细胞定位。
影响因子：
3.8
作者：
Trebinska A;Rembiszewska A;Ciosek K;Ptaszynski K;Rowinski S;Kupryjanczyk J;Siedlecki JA;Grzybowska EA
通讯作者：
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作者：
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影响因子：
11.1
作者：
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影响因子：
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作者：
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通讯作者：
Ray, Ranjit