CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancer.
CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancer.
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DOI：
10.3390/ijms13056399
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发表时间：
2012
影响因子：
5.6
通讯作者：
Zeng HZ
中科院分区：
文献类型：
--
作者：
Liu WF;Ji SR;Sun JJ;Zhang Y;Liu ZY;Liang AB;Zeng HZ
CD146被认为是治疗多种癌症的一个新的潜在靶点。本研究旨在探讨CD146在胃癌中的表达，并评价其临床病理和预后意义。采用免疫组化方法检测144例胃癌组织中CD146及3种上皮-间质转化相关蛋白（E-cadherin、β-catenin、vimentin）的表达。59例（41.0%）CD146表达阳性。我们发现CD146表达与淋巴结受累和不良预后呈正相关，并保留了胃癌患者的独立预后因素。此外，CD146的阳性表达与上皮标记物E-cadherin的缺失以及间质标记物核β-catenin和vimentin的表达获得密切相关。这些发现提示CD146可能促进胃癌的EMT和进展，因此可能是胃癌患者的潜在治疗靶点。
CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance. The expression of CD146 and three epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, β-catenin and vimentin) was examined in 144 gastric cancers by immunohistochemistry. Fifty-nine cases (41.0%) were defined as positive for CD146 expression. We found that CD146 expression correlated positively with lymph node involvement and a poor prognosis, and retained an independent prognostic factor for gastric cancer patients. Furthermore, positive expression of CD146 was strongly associated with loss of the epithelial marker E-cadherin and acquisition of the expression of the mesenchymal markers nuclear β-catenin and vimentin. These findings suggest that CD146 might promote EMT and progression in gastric cancer, and thus may be a potential therapeutic target for patients with gastric cancers.
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影响因子：
3.3
作者：
Ryu, Han Suk;Park, Do Joong;Lee, Hye Seung
通讯作者：
Lee, Hye Seung
影响因子：
6.6
作者：
Wu, GJ;Fu, PP;Wu, MWH
通讯作者：
Wu, MWH
影响因子：
4.3
作者：
Lin, Yingsong;Ueda, Junko;Inoue, Manami
通讯作者：
Inoue, Manami
影响因子：
6.4
作者：
Aldovini, Daniela;Demichelis, Francesca;Barbareschi, Mattia
通讯作者：
Barbareschi, Mattia
DOI：
10.1186/bcr2215
发表时间：
2009
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Zabouo G;Imbert AM;Jacquemier J;Finetti P;Moreau T;Esterni B;Birnbaum D;Bertucci F;Chabannon C
通讯作者：
Chabannon C