Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study.
Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study.
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DOI：
10.1016/j.nbd.2018.04.015
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发表时间：
2018-08
影响因子：
6.1
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Wang H;Atik A;Stewart T;Ginghina C;Aro P;Kerr KF;Seibyl J;Jennings D;PARS Investigators;Jensen PH;Marek K;Shi M;Zhang J
Plasma total and nervous system derived exosomal (NDE) α-synuclein have been determined as potential biomarkers of Parkinson’s disease (PD). To explore the utility of plasma α-synuclein in the prodromal phase of PD, plasma total and NDE α-synuclein were evaluated in baseline and 2-year follow-up samples from 256 individuals recruited as part of the Parkinson’s Associated Risk Syndrome (PARS) study. The results demonstrated that baseline and longitudinal increases in total α-synuclein predicted progression of cognitive decline in hyposmic individuals with dopamine transporter (DAT) binding reduction. On the other hand, a longitudinal decrease in NDE α-synuclein predicted worsening cognitive scores in hyposmic individuals with DAT binding reduction. Finally, in individuals with faster DAT progression, decreasing NDE/total α-synuclein ratio was associated with a larger reduction in DAT from baseline to follow-up. These results suggest that, though underlying mechanisms remain to be defined, alterations in plasma total and NDE α-synuclein concentrations are likely associated with PD progression, especially in the aspect of cognitive impairment, at early stages of the disease.
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DOI：
10.1016/j.jalz.2016.08.012
发表时间：
2017-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Hamlett ED;Goetzl EJ;Ledreux A;Vasilevko V;Boger HA;LaRosa A;Clark D;Carroll SL;Carmona-Iragui M;Fortea J;Mufson EJ;Sabbagh M;Mohammed AH;Hartley D;Doran E;Lott IT;Granholm AC
通讯作者：
Granholm AC
影响因子：
8.6
作者：
Gonera, EG;vantHof, M;Horstink, WIM
通讯作者：
Horstink, WIM
影响因子：
--
作者：
Mata, Ignacio F.;Shi, Min;Agarwal, Pinky;Chung, Kathryn A.;Edwards, Karen L.;Factor, Stewart A.;Galasko, Douglas R.;Ginghina, Carmen;Griffith, Alida;Higgins, Donald S.;Kay, Denise M.;Kim, Hojoong;Leverenz, James B.;Quinn, Joseph F.;Roberts, John W.;Samii, Ali;Snapinn, Katherine W.;Tsuang, Debby W.;Yearout, Dora;Zhang, Jing;Payami, Haydeh;Zabetian, Cyrus P.
通讯作者：
Zabetian, Cyrus P.
影响因子：
9.9
作者：
Ahn, T. -B.;Kim, S. Y.;Jeon, B. S.
通讯作者：
Jeon, B. S.
影响因子：
14.5
作者：
Hong, Zhen;Shi, Min;Zhang, Jing
通讯作者：
Zhang, Jing